5-chloro-2-{[5-chloro-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazol-2-yl]oxy}benzenesulfonamide | 1022251-47-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-chloro-2-{[5-chloro-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazol-2-yl]oxy}benzenesulfonamide
• 英文别名: 5-Chloro-2-(5-chloro-4-methoxy-1-methyl-7-pentan-3-ylbenzimidazol-2-yl)oxybenzenesulfonamide
• CAS: 1022251-47-3
• 化学式: C₂₀H₂₃Cl₂N₃O₄S
• 分子量: 472.392
• InChiKey: PZOKFEJFRAVWIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(2-bromo-4-chlorophenoxy)-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazole 在 正丁基锂 、 二氧化硫 、 磺酰氯 、 氨 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.41h， 以12%的产率得到5-chloro-2-{[7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazol-2-yl]oxy}benzenesulfonamide
  参考文献：
  名称：

  WO2008/51533

  摘要：

  公开号：

文献信息

• BENZIMIDAZOLE COMPOUNDS
  申请人：Aso Kazuyoshi

  公开号：US20100056515A1

  公开（公告）日：2010-03-04

  There is provided a compound of the formula (I): wherein R 1 is an optionally substituted C 1-10 alkyl; R 2 is H, or a C 1-6 alkyl which may be substituted with 1 to 3 substituents; R 3 is a 5- or 6-membered aromatic group which may be substituted with 1 to 5 substituents, wherein the 5- or 6-membered aromatic group may be fused with a 5- or 6-membered ring which may be substituted with 1 to 3 C 1-6 alkyls; R 4 is a hydrogen, a halogen, a hydroxy, a cyano, a C 1-6 alkyl or a C 1-6 alkoxy; Z is —O—, —S—, —SO—, —SO 2 —, or —NR 5 — wherein R 5 is a hydrogen or a C 1-6 alkyl; or a salt thereof or a prodrug thereof, which have CRF receptor antagonist activity and use thereof.

  提供了一个式子(I)的化合物： 其中，R1是可选取代的C1-10烷基；R2是氢，或者是一个C1-6烷基，该烷基可以用1至3个取代基取代；R3是一个5-或6-成员芳香基团，可以用1至5个取代基取代，其中5-或6-成员芳香基团可以与一个5-或6-成员环融合，该环可以用1至3个C1-6烷基取代；R4是氢、卤素、羟基、氰基、C1-6烷基或C1-6烷氧基；Z是-O-、-S-、-SO-、-SO2-或-NR5-，其中R5是氢或C1-6烷基；或其盐或前药，具有CRF受体拮抗活性和使用方法。
• Naphthalenylsulfonylimidazolidinediones and their thioxo analogs
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0251784A2

  公开（公告）日：1988-01-07

  The invention comprises naphthalenylsulfonylimidazolidinediones of formula (I) wherein R⁴, R⁵, R⁶ and R⁷ are hydrogen, halogen, trifluoromethyl, methoxy or dimethylamino and X is oxygen or sulfur and the pharmaceutically acceptable salts thereof, and methods for their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications. Pharmaceutical compositions containing the compounds and methods for manufacturing same are also included in the invention.

  本发明包括式 (I) 的萘基磺酰亚胺唑烷二酮，其中 R⁴、R⁵、R⁶ 和 R⁷ 是氢、卤素、三氟甲基、甲氧基或二甲基氨基，X 是氧或硫及其药学上可接受的盐，以及它们的制备方法。 这些化合物是新型醛糖还原酶抑制剂，可用于治疗或预防糖尿病并发症。 本发明还包括含有这些化合物的药物组合物及其生产方法。
• SUCCESSIVELY BIAXIAL-ORIENTED POROUS POLYPROPYLENE FILM AND PROCESS FOR PRODUCTION THEREOF
  申请人：NEW JAPAN CHEMICAL CO.,LTD.

  公开号：EP1369221A1

  公开（公告）日：2003-12-10

  Disclosed is a successively biaxially stretched film obtained by successive biaxial stretching method comprising extruding a melt of a β-crystal nucleating agent-containing polypropylene-based resin composition from a T-die, cooling the extruded resin on a chill roll, and stretching the resulting web sheet longitudinally and then transversely, wherein the longitudinally stretched sheet is made to have a degree of β-crystal orientation of less than 0.3 by the following method (I) and/or (II), optionally subjected to annealing treatment, and transversely stretched: method (I): melting the polypropylene-based resin composition containing needle crystals of a specific β-crystal nucleating agent at a temperature not lower than m.p. of the polypropylene-based resin and lower than dissolution temperature of the β-crystal nucleating agent in the polypropylene-based resin melt, and extruding the melt from the T-die at the same temperature, method (II): adjusting neck-in ratio during longitudinal stretching to 25 to 55%. The porous polypropylene film has good breakage resistance during manufacture, excellent thickness uniformity, high porosity and air-permeability, and is useful for battery separators.

  本发明公开了一种通过连续双轴拉伸方法获得的连续双轴拉伸薄膜，该连续双轴拉伸方法包括从T型模头挤出含β晶成核剂的聚丙烯基树脂组合物的熔体，在冷却辊上冷却挤出的树脂，然后纵向拉伸所得腹板，再横向拉伸所得腹板，其中纵向拉伸的腹板通过以下方法使β晶取向度小于0.3，可选择进行退火处理，然后进行横向拉伸： 方法 (I)：在不低于聚丙烯基树脂熔融温度和不低于聚丙烯基树脂熔体中 β 结晶成核剂溶解温度的条件下，熔化含有特定 β 结晶成核剂针状晶体的聚丙烯基树脂组合物，并在相同温度下从 T 型模 具挤出熔体、 方法 (II)：在纵向拉伸过程中将缩颈率调整为 25%至 55%。 这种多孔聚丙烯薄膜在制造过程中具有良好的抗破损性、优异的厚度均匀性、高孔隙率和透气性，可用于电池隔膜。
• Successively biaxial-oriented porous polypropylene film and process for production thereof
  申请人：——

  公开号：US20040096744A1

  公开（公告）日：2004-05-20

  Disclosed is a successively biaxially stretched film obtained by successive biaxial stretching method comprising extruding a melt of a &bgr;-crystal nucleating agent-containing polypropylene-based resin composition from a T-die, cooling the extruded resin on a chill roll, and stretching the resulting web sheet longitudinally and then transversely, wherein the longitudinally stretched sheet is made to have a degree of &bgr;-crystal orientation of less than 0.3 by the following method (I) and/or (II), optionally subjected to annealing treatment, and transversely stretched: method (I): melting the polypropylene-based resin composition containing needle crystals of a specific &bgr;-crystal nucleating agent at a temperature not lower than m.p. of the polypropylene-based resin and lower than dissolution temperature of the &bgr;-crystal nucleating agent in the polypropylene-based resin melt, and extruding the melt from the T-die at the same temperature, method (II): adjusting neck-in ratio during longitudinal stretching to 25 to 55%. The porous polypropylene film has good breakage resistance during manufacture, excellent thickness uniformity, high porosity and air-permeability, and is useful for battery separators.
• US7235203B2
  申请人：——

  公开号：US7235203B2

  公开（公告）日：2007-06-26