(3R,4S)-3-benzoyl-6-methoxy-4-methylchroman-2-one | 1194476-68-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4S)-3-benzoyl-6-methoxy-4-methylchroman-2-one
• CAS: 1194476-68-0
• 化学式: C₁₈H₁₆O₄
• 分子量: 296.323
• InChiKey: SFSMPZUYHYLLKL-BDJLRTHQSA-N

反应信息

• 作为产物：
  描述：

  3-benzoyl-6-methoxy-2H-chromen-2-one 、 三甲基铝 在 (R,R)-(PhMeCH)2N-P(-2-O-3,5-diMe-C₆H₂-C₆H₂-3',5'-diMe-2'-O-) 、 copper(II) acetate monohydrate 作用下， 以 乙醚 为溶剂， 反应 20.0h， 生成 (3S,4R)-3-benzoyl-6-methoxy-4-methylchroman-2-one 、 (3R,4S)-3-benzoyl-6-methoxy-4-methylchroman-2-one 、 3-benzoyl-6-methoxy-4-methylchroman-2-one
  参考文献：
  名称：

  Asymmetric conjugate additions to 1,1′-diactivated cyclic enones—a comparative study

  摘要：

  A study of copper-phosphoramidite-catalysed ZnR2 and AlR3 additions to 1,1'-dicarbonyl-activated cyclic Michael acceptors has revealed high enantioselectivities for AlR3 (R = Me, Et) 1,4-addition to a range of 3-acylcoumarins (85-98% ee, trans:cis similar to 90:10) using commercial OF readily available ligands. Large substituents at the 6-position, and to some extent at the 5-position, of the coumarin are less well tolerated, nor is truncation of the coumarin motif to a comparable 2-acylcyclohexenone (ee values up to 78%). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.006