| 1187830-35-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1187830-35-8
• 化学式: C₁₅H₂₃NO₆
• 分子量: 313.351
• InChiKey: FAEFPTSSIOLBCE-QZOBBIQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.41
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  111.41
• 氢给体数：
  5.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 palladium 10% on activated carbon 、 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Access to Ring-Expanded Analogues of 2-Amino Sugars

  摘要：

  Ring-expanded 2-N-acetylamino sugar analogs Of D-glucose, D-galactose, and D-mannose have been prepared by a new synthetic route. Aspects of the highly substituted (x-amino aldehyde intermediates made them central to the approach, First, they were accessed via diastereoselective addition of a vinyl Grignard onto protected glycosyl amines. Also, the sterics of the bis-protected amine favored the formation of only one glycoside anomer. The new analogues reported here should prove useful in the development of tools to investigate the role of 2-amino sugars in biology.

  DOI：

  10.1021/ol9018387
• 作为产物：
  描述：

  (2S,3S,4S,5R,6R,7R)-N-benzyl-4,5,6-tris(benzyloxy)-7-((benzyloxy)methyl)-2-methoxyoxepan-3-amine 在 20% Pd(OH)2/C 、 氢气 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 12.0h， 以83%的产率得到
  参考文献：
  名称：

  Access to Ring-Expanded Analogues of 2-Amino Sugars

  摘要：

  Ring-expanded 2-N-acetylamino sugar analogs Of D-glucose, D-galactose, and D-mannose have been prepared by a new synthetic route. Aspects of the highly substituted (x-amino aldehyde intermediates made them central to the approach, First, they were accessed via diastereoselective addition of a vinyl Grignard onto protected glycosyl amines. Also, the sterics of the bis-protected amine favored the formation of only one glycoside anomer. The new analogues reported here should prove useful in the development of tools to investigate the role of 2-amino sugars in biology.

  DOI：

  10.1021/ol9018387