二碳酸二甲酯 | 1144516-13-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 二碳酸二甲酯
• 英文名称: AY5Ecq7B2D
• 英文别名: 2-[[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]amino]-2-oxoacetic acid
• CAS: 1144516-13-1
• 化学式: C₂₆H₂₀ClN₅O₅
• 分子量: 517.9
• InChiKey: LJBZJAUBLJREAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  147
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Maleate Salts of (E)-N--4-(Dimethylamino)-2-Butenamide and Crystalline Forms Thereof
  申请人：Lu Qinghong

  公开号：US20120289545A1

  公开（公告）日：2012-11-15

  The present invention relates to maleate salt forms of (E)-N-4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

  本发明涉及(E)-N-4-[3-氯-4-(2-吡啶基甲氧基)苯氨基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲氨基)-2-丁烯酰胺的马来酸盐形式，制备晶体马来酸盐形式的方法，相关化合物以及含有它们的制药组合物。这些马来酸盐在治疗癌症方面有用，特别是那些受表皮生长因子受体家族激酶影响的癌症。
• MALEATE SALTS OF (E)-N-{4-[3-CHLORO-4-(2-PYRIDINYLMETHOXY)ANILINO]-3-CYANO-7-ETHOXY-6-QUINOLINYL}-4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
  申请人：Wyeth LLC

  公开号：EP3088398A1

  公开（公告）日：2016-11-02

  The present invention relates to isolated crystalline forms of (E)-N-4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate and to pharmaceutical compositions comprising the same.

  本发明涉及(E)-N-4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰-7-乙氧基-6-喹啉基}-4-(二甲氨基)-2-丁烯酰胺盐酸盐的分离晶体形式以及包含它们的制药组合物。
• MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
  申请人：Wyeth LLC

  公开号：US20130281488A1

  公开（公告）日：2013-10-24

  The present invention relates to maleate salt forms of (E)-N-4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

  本发明涉及(E)-N-4-[3-氯-4-(2-吡啶甲氧基)苯氨基]-3-氰-7-乙氧基-6-喹啉基}-4-(二甲基氨基)-2-丁烯酰胺的马来酸盐形式，制备晶体马来酸盐形式的方法，相关化合物以及含有它们的药物组合物。这些马来酸盐在治疗癌症中有用，特别是那些受表皮生长因子受体家族激酶影响的癌症。
• MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
  申请人：Wyeth LLC

  公开号：US20160068511A1

  公开（公告）日：2016-03-10

  The present invention relates to maleate salt forms of (E)-N-4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

  本发明涉及(E)-N-4-[3-氯-4-(2-吡啶甲氧基)苯氨基]-3-氰-7-乙氧基-6-喹啉基}-4-(二甲氨基)-2-丁烯酰胺的马来酸盐形式，制备晶体马来酸盐形式的方法，相关化合物以及含有它们的制药组合物。这些马来酸盐对于治疗癌症特别是那些受表皮生长因子受体家族激酶影响的癌症是有用的。
• Preparation of maleate salt of neratininb and its use
  申请人：Wyeth LLC

  公开号：EP2537843A2

  公开（公告）日：2012-12-26

  The present invention relates to maleate salt forms of (E)-N-4-[3-chloro-4-(2-pyridinylmethoxy]anilino}-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

  本发明涉及(E)-N-4-[3-氯-4-(2-吡啶基甲氧基)苯胺基}-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲基氨基)-2-丁烯酰胺的马来酸盐形式、制备结晶马来酸盐形式的方法、相关化合物以及含有这些化合物的药物组合物。马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。