2-isopropylquinoline-6-carboxylic acid | 958331-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-isopropylquinoline-6-carboxylic acid
• 英文别名: 2-Propan-2-ylquinoline-6-carboxylic acid
• CAS: 958331-67-4
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: AGRYRWLAEVHXJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
  申请人：Shishido Yuji

  公开号：US20120088746A1

  公开（公告）日：2012-04-12

  Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  披露了具有以下公式表示的化合物：公式（I）。这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如疼痛、炎症、创伤性损伤等。
• ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US20190248777A1

  公开（公告）日：2019-08-15

  The present invention provides compounds of Formula (I): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.

  本发明提供了公式(I)的化合物：包括这些化合物的制药组合物以及使用这些化合物治疗或预防由FXR介导的疾病或紊乱的方法。具体而言，本发明涉及用作FXR激动剂的异噁唑衍生物，以及它们的制备和使用方法。
• Isoxazole derivatives as FXR agonists and methods of use thereof
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US10829486B2

  公开（公告）日：2020-11-10

  The present invention provides compounds of Formula (I): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.

  本发明提供了式 (I) 的化合物： 包含这些化合物的药物组合物，以及使用这些化合物治疗或预防由 FXR 介导的疾病或紊乱的方法。具体而言，本发明涉及可用作 FXR 激动剂的异噁唑衍生物及其制备和使用方法。
• [EN] AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME<br/>[FR] DÉRIVÉS D'AMIDES EN TANT QUE LIGANDS DE CANAL IONIQUE ET COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES D'UTILISATION DESDITS DÉRIVÉS
  申请人：RENOVIS INC

  公开号：WO2007133637A2

  公开（公告）日：2007-11-22

  [EN] Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
  [FR] La présente invention porte sur des composés de formule suivante : Formule (I). Les composés peuvent être élaborés sous forme de compositions pharmaceutiques, et peuvent être employés dans le traitement prophylactique et thérapeutique de divers états pathologiques chez les mammifères, y compris les êtres humains, ce qui inclut, mais sans y être limité, la douleur, l'inflammation, les lésions traumatiques, entre autres.
• [EN] ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS D'ISOXAZOLE EN TANT QU'AGONISTES DE FXR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ENANTA PHARM INC

  公开号：WO2019160813A1

  公开（公告）日：2019-08-22

  The present invention provides compounds of Formula (I): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.