5-hydroxy-1-tert-butyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one | 1174017-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-hydroxy-1-tert-butyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one
• 英文别名: 1-Tert-butyl-5-hydroxy-3,3a,4,5-tetrahydrocyclopenta[c]acridin-2-one
• CAS: 1174017-10-7
• 化学式: C₂₀H₂₁NO₂
• 分子量: 307.392
• InChiKey: QLWQIYOCUAVQPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TETRAHYDROCYCLOPENTA[C]ACRIDINE DERIVATIVES AS KINASE INHIBITORS AND BIOLOGICAL
  申请人：Belmont Philippe Olivier

  公开号：US20100285124A1

  公开（公告）日：2010-11-11

  The invention relates to kinase inhibitors of the formula (I) in which —R 1 to R 4 =H; ether or polyether, amino; NO 2 ; NH— carbamate; NH—CO—R, with R such as defined above; N 3 and derivatives thereof of the 1,2,3-triazole type; —R 5 =—OH; halogen; —OR with R such as defined above; OH-carbamate; OH-carbonate; NH 2 , NH-carbamate; NH—CO—R, with R such as defined above; N 3 and derivatives thereof of the 1,2,3-triazole type; N(R 9 , R 10 ); —R 5 ′=H or a C1-C12 alkyl, —R 6 =H; R; (R or R′) 3 —Si, with R such as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; —R 7 and R 8 =H, C 1 -C 12 alkyl; —R 9 and R 10 =H, R (or R′) such as defined above. These compounds can be used as kinase inhibitors in particular for treating cancer.

  这项发明涉及公式（I）的激酶抑制剂，其中-R1至R4=H；醚或聚醚，氨基；NO2；NH-碳酸酯；NH-CO-R，其中R如上所定义；N3及其1,2,3-三唑类衍生物；-R5=-OH；卤素；-OR，其中R如上所定义；OH-碳酸酯；OH-碳酸酯；NH2，NH-碳酸酯；NH-CO-R，其中R如上所定义；N3及其1,2,3-三唑类衍生物；N（R9，R10）；-R5′=H或C1-C12烷基，-R6=H；R；（R或R'）3-Si，其中R如上所定义；可选择地取代的芳基，杂环芳基；卤素（碘）；炔基；-R7和R8=H，C1-C12烷基；-R9和R10=H，R（或R'）如上所定义。这些化合物可以作为激酶抑制剂，特别用于治疗癌症。
• US8999955B2
  申请人：——

  公开号：US8999955B2

  公开（公告）日：2015-04-07