8-(5-Fluoro-8-quinolinyl)-1,4-dioxa-8-azaspiro[4.5]decane | 917251-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(5-Fluoro-8-quinolinyl)-1,4-dioxa-8-azaspiro[4.5]decane
• 英文别名: 8-(5-fluoroquinolin-8-yl)-1,4-dioxa-8-azaspiro[4.5]decane
• CAS: 917251-77-5
• 化学式: C₁₆H₁₇FN₂O₂
• 分子量: 288.32
• InChiKey: XKJFSYXBXLLAJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor
  申请人：Asselin Magda

  公开号：US20070027160A1

  公开（公告）日：2007-02-01

  The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT 1A binding agents, particularly as 5-HT 1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction.

  本发明涉及新型哌嗪-哌啶化合物。这些化合物可用作5-HT1A结合剂，特别是作为5-HT1A受体拮抗剂和激动剂。这些化合物在治疗中枢神经系统疾病方面很有用，如认知障碍、焦虑症、抑郁症和性功能障碍。
• Processes for synthesizing piperazine-piperidine compounds
  申请人：Liu Weiguo

  公开号：US20080058523A1

  公开（公告）日：2008-03-06

  The present invention relates to processes for synthesizing piperazine-piperidine compounds, and compounds useful as 5-HT 1A binding agents, particularly as 5-HT 1A receptor antagonists and agonists. The processes also allow for safer and environmentally tolerant production of these useful compounds.

  本发明涉及合成哌嗪-哌啶化合物的过程，以及用作5-HT1A结合剂的化合物，特别是5-HT1A受体拮抗剂和激动剂。这些过程还允许更安全、更环保地生产这些有用的化合物。
• Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof
  申请人：Wang Jianyao

  公开号：US20080262228A1

  公开（公告）日：2008-10-23

  The present invention relates to novel metabolites of 5-Fluoro-8-4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}quinoline, which can be useful in treating CNS disorders. The present invention further relates to processes for their preparation, to pharmaceutical compositions comprising them, and to methods of using them.

  本发明涉及5-氟-8-4-[4-(6-甲氧基喹啉-8-基)哌嗪-1-基]哌啶-1-基}喹啉的新代谢产物，可用于治疗中枢神经系统疾病。本发明还涉及其制备方法、包含它们的药物组合物以及使用它们的方法。
• US7671056B2
  申请人：——

  公开号：US7671056B2

  公开（公告）日：2010-03-02