2-(4-Tolyl)-4-hydroxymethyl-imidazol | 43002-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-Tolyl)-4-hydroxymethyl-imidazol
• 英文别名: 2-Tolyl-4-hydroxymethylimidazol；(2-p-tolyl-1(3)H-imidazol-4-yl)-methanol；2-(p-Tolyl)imidazole-5-methanol；[2-(4-methylphenyl)-1H-imidazol-5-yl]methanol
• CAS: 43002-55-7
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: NWXSBLKHDZDTRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-Tolyl)-4-hydroxymethyl-imidazol 、 半胱胺盐酸盐 以29%的产率得到
  参考文献：
  名称：

  DZIURON P.; SCHUNACK W., ARCH. PHARM. , 1976, 309, NO 7, 583-586

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基苯甲脒盐酸盐 、 1,1-二羟基丙烷-2-酮 、 氯化铵 以 ammonium hydroxide 为溶剂， 反应 4.0h， 以to yield 3.0 g 2-(4-methylphenyl)-5-hydroxymethyl-imidazole which的产率得到2-(4-Tolyl)-4-hydroxymethyl-imidazol
  参考文献：
  名称：

  4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives,

  摘要：

  本发明涉及以下式的化合物：##STR1## 其中，R.sub.1代表可选择取代的芳基，杂环芳基，芳基烷基或环烷基基团；X，Z和Y是可选择取代的氮或碳原子；R.sub.3和R.sub.4是有机或无机取代基，它们可以一起形成环状结构；m为零，一或二；而R.sub.5和R.sub.6是有机或无机取代基；以及其药学上可接受的加合盐，这些化合物是高度选择性的部分激动剂或拮抗剂，在脑多巴胺受体亚型或其前药中有用，可用于诊断和治疗情感障碍，如精神分裂症和抑郁症，以及某些运动障碍，如帕金森病。

  公开号：

  US05656762A1

文献信息

• Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands
  申请人：Neurogen Corporation, Corporation of the State of Delaware

  公开号：US20030018025A1

  公开（公告）日：2003-01-23

  Disclosed are compounds of the formula: 1 wherein R 1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R 3 and R 4 are organic or inorganic substitutents which may togther form ring structutes; m is zero, one or two; and R 5 and R 6 are are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

  揭示了以下式的化合物： 其中R1代表可选择地取代的芳基、杂环芳基、芳基烷基或环烷基基团；X、Z和Y为可选择地取代的氮或碳原子；R3和R4为有机或无机取代基，可能共同形成环结构；m为零、一或二；R5和R6为有机或无机取代基； 以及其药学上可接受的盐， 这些化合物是高度选择性的部分激动剂或拮抗剂，作用于脑多巴胺受体亚型或其前药，并可用于诊断和治疗情感障碍，如精神分裂症和抑郁症，以及某些运动障碍，如帕金森病。
• 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives;
  申请人：Neurogen Corporation

  公开号：US05633377A1

  公开（公告）日：1997-05-27

  Disclosed are compounds of the formula: ##STR1## wherein R.sub.1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R.sub.3 and R.sub.4 are organic or inorganic substitutents which may together form ring structures; m is zero, one or two; and R.sub.5 and R.sub.6 are are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

  本发明涉及一种公式为：##STR1##的化合物，其中R.sub.1代表可选取代的芳基、杂环芳基、芳基烷基或环烷基基团；X、Z和Y是可选取代的氮或碳原子；R.sub.3和R.sub.4是有机或无机取代基，它们可以一起形成环结构；m为零、一或二；R.sub.5和R.sub.6是有机或无机取代基；以及其药学上可接受的盐。这些化合物是高度选择性的部分激动剂或拮抗剂，可作为脑多巴胺受体亚型或其前药在情感障碍，如精神分裂症和抑郁症以及某些运动障碍，如帕金森症的诊断和治疗中使用。
• Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole
  申请人：Neurogen Corporation

  公开号：US05646281A1

  公开（公告）日：1997-07-08

  Disclosed are compounds of the formula: ##STR1## wherein R.sub.1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R.sub.3 and R.sub.4 are organic or inorganic substituents which may together form ring structures; m is zero, one or two; and R.sub.5 and R.sub.6 are are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

  本发明涉及以下化合物：##STR1## 其中R.sub.1代表可选取代的芳基，杂环芳基，芳基烷基或环烷基基团；X，Z和Y是可选取代的氮或碳原子；R.sub.3和R.sub.4是有机或无机取代基，可以共同形成环结构；m为零、一或二；R.sub.5和R.sub.6是有机或无机取代基；以及其药学上可接受的加合盐。这些化合物是高度选择性的部分激动剂或拮抗剂，可作为脑多巴胺受体亚型的诊断和治疗工具，用于情感障碍，如精神分裂症和抑郁症，以及某些运动障碍，如帕金森病。
• Certain 4-piperidine- and piperazinoalkyl-2-phenyl imidazole
  申请人：Neurogen Corporation

  公开号：US05712392A1

  公开（公告）日：1998-01-27

  Disclosed are compounds of the formula ##STR1## wherein R.sub.1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R.sub.3 and R.sub.4 are organic or inorganic substituents which may together form ring structures; m is zero, one or two; and R.sub.5 and R.sub.6 are are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

  本发明揭示了化合物的公式 ##STR1## 其中R.sub.1代表可选的取代芳基，杂环芳基，芳基烷基或环烷基基团; X，Z和Y是可选的取代氮或碳原子; R.sub.3和R.sub.4是有机或无机取代基，它们可以共同形成环结构; m为零，一或二; R.sub.5和R.sub.6是有机或无机取代基;以及其药学上可接受的加盐物，这些化合物是高度选择性的部分激动剂或拮抗剂，对大脑多巴胺受体亚型或其前药，对情感障碍如精神分裂症和抑郁症以及某些运动障碍如帕金森病的诊断和治疗非常有用。
• Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
  申请人：Neurogen Corporation

  公开号：US20020143044A1

  公开（公告）日：2002-10-03

  Disclosed are compounds of the formula: 1 wherein R 1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R 3 and R 4 are organic or inorganic substitutents which may together form ring structutes; m is zero, one or two; and R 5 and R 6 are are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

  本发明涉及以下公式的化合物：1其中，R1代表可选取代的芳基，杂芳基，芳基烷基或环烷基基团；X，Z和Y是可选取代的氮或碳原子；R3和R4是有机或无机取代基，它们可以共同形成环结构；m为零，一或二；R5和R6是有机或无机取代基；以及其药学上可接受的盐。这些化合物是高度选择性的部分激动剂或拮抗剂，适用于诊断和治疗情感障碍，如精神分裂症和抑郁症以及某些运动障碍，如帕金森病。