α-(3-Methoxy-benzyliden)-bernsteinsaeure | 93305-68-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: α-(3-Methoxy-benzyliden)-bernsteinsaeure
• 英文别名: 2-[(3-Methoxyphenyl)methylidene]butanedioic acid
• CAS: 93305-68-1
• 化学式: C₁₂H₁₂O₅
• 分子量: 236.224
• InChiKey: HKNKNDBCYPNSJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel butadiene derivatives, process for preparation of the same and intermediates for the synthesis thereof
  申请人：——

  公开号：US20040180938A1

  公开（公告）日：2004-09-16

  A butadiene derivative having an excellent inhibitory activity on the PAI-1, which is represented by the general formula [I]: 1 wherein R 1 is a hydrogen atom or a lower alkyl group, R 2 is a lower alkyl group, R 3 is a lower alkoxy group, R 4 is a hydrogen atom or a lower alkyl group, R 5 is a lower alkyl group, or a pharmaceutically acceptable salt thereof, a process a process for preparing the same and an intermediate thereof.

  一种丁二烯衍生物，具有卓越的对PAI-1的抑制活性，其通式表示为[I]：其中R1为氢原子或较低的烷基，R2为较低的烷基，R3为较低的烷氧基，R4为氢原子或较低的烷基，R5为较低的烷基，或其药学上可接受的盐，以及其制备方法和中间体。
• Method for preparing (R)-succinic acid derivatives
  申请人：MONSANTO COMPANY

  公开号：EP0380463A2

  公开（公告）日：1990-08-01

  Method for preparing a biologically active 2-substituted succinic acid derivative involving asymmetrically catalytically hydrogenating the corresponding 2(E)-alkylidene succinate derivative in the presence of a rhodium complexed (R,R)-bisphosphine compound.

  制备具有生物活性的 2-取代琥珀酸衍生物的方法，包括在铑络合 (R,R)-二膦化合物存在下，不对称催化氢化相应的 2(E)-亚烷基琥珀酸衍生物。
• NOVEL BUTADIENE DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND INTERMEDIATES FOR THE SYNTHESIS THEREOF
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP1403252A1

  公开（公告）日：2004-03-31

  A butadiene derivative having an excellent inhibitory activity on the PAI-1, which is represented by the general formula [I]: wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a lower alkyl group, R3 is a lower alkoxy group, R4 is a hydrogen atom or a lower alkyl group, R5 is a lower alkyl group, or a pharmaceutically acceptable salt thereof, a process a process for preparing the same and an intermediate thereof.

  一种对PAI-1具有优异抑制活性的丁二烯衍生物，由通式[I]表示： 其中 R1 为氢原子或低级烷基，R2 为低级烷基，R3 为低级烷氧基，R4 为氢原子或低级烷基，R5 为低级烷基，或其药学上可接受的盐、制备方法及其中间体。
• US4939288A
  申请人：——

  公开号：US4939288A

  公开（公告）日：1990-07-03