β,δ-Dioxocaproaldehyd-diethylacetal | 28787-33-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β,δ-Dioxocaproaldehyd-diethylacetal
• 英文别名: 6,6-Diethoxyhexane-2,4-dione
• CAS: 28787-33-9
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: BKTMHEDMUAKSAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• MACROCYCLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170057961A1

  公开（公告）日：2017-03-02

  The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
• MACROCYCLIC FACTOR XIA INHIBITORS BEARING HETEROCYCLIC GROUPS
  申请人：Bristol-Myers Squibb Company

  公开号：US20180222907A1

  公开（公告）日：2018-08-09

  The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.