(S)-5-(methoxymethoxy)-5-methyloctanal | 1262205-96-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-5-(methoxymethoxy)-5-methyloctanal
• CAS: 1262205-96-8
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.294
• InChiKey: QIQUDYCROONYBG-NSHDSACASA-N

反应信息

• 作为产物：
  描述：

  在 20 % Pd(OH)2/C 、 氢气 作用下， 以 苯 为溶剂， 以90%的产率得到(S)-5-(methoxymethoxy)-5-methyloctanal
  参考文献：
  名称：

  Palladium Hydroxide Catalyzed Isomerization of Primary Allylic Alcohols to Aldehydes: Application to the Formal Synthesis of (−)-Brevisamide

  摘要：

  The Pd-catalyzed isomerization of primary allylic alcohols into the corresponding saturated aldehydes has been achieved at room temperature for the first time in good to excellent yields under mild conditions. The functional group compatibility in this reaction is studied, and this new methodology has been successfully applied in the synthesis of a C5-C13 tetrahydropyran ring system of (-)-brevisamide in seven steps.

  DOI：

  10.1021/ol102658d