1,3-bis[O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)]propane-1,3-diol | 1105508-51-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,3-bis[O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)]propane-1,3-diol
• CAS: 1105508-51-7
• 化学式: C₃₁H₄₄O₂₀
• 分子量: 736.678
• InChiKey: BEWBRHRSSDLNMB-LVLLTTCXSA-N

反应信息

• 作为反应物：
  描述：

  1,3-bis[O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)]propane-1,3-diol 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以71%的产率得到1,3-bis[O-(α-D-mannopyranosyl)]propane-1,3-diol
  参考文献：
  名称：

  Synthesis and AFM studies of lectin–carbohydrate self-assemblies

  摘要：

  Lectins are carbohydrate-binding proteins found in plants, viruses, bacteria, and animal cells having the ability to distinguish complex carbohydrate structures on cell surfaces. The ubiquity of lectin-carbohydrate interactions support the notion of a glycocode, which is related to highly specific recognition of carbohydrate display expressed on different cell surfaces of normal and diseased origin. The importance of these interactions in cell biology and medicine has been realized with the -applications ranging from blood typing to clinical diagnostics. This paper reports synthesis of some symmetrical carbohydrate derivatives, their interaction with lectin Concanavalin A and ultrastructural force microscopic studies of the complex formation. Preliminary efforts have been made to construct possible models to explain the nature of interaction within these assemblies. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.055
• 作为产物：
  描述：

  1,3-丙二醇 、 1,2,3,4,6-O-五乙酰基-Alpha-甘露糖 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 以51%的产率得到1,3-bis[O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)]propane-1,3-diol
  参考文献：
  名称：

  Synthesis and AFM studies of lectin–carbohydrate self-assemblies

  摘要：

  Lectins are carbohydrate-binding proteins found in plants, viruses, bacteria, and animal cells having the ability to distinguish complex carbohydrate structures on cell surfaces. The ubiquity of lectin-carbohydrate interactions support the notion of a glycocode, which is related to highly specific recognition of carbohydrate display expressed on different cell surfaces of normal and diseased origin. The importance of these interactions in cell biology and medicine has been realized with the -applications ranging from blood typing to clinical diagnostics. This paper reports synthesis of some symmetrical carbohydrate derivatives, their interaction with lectin Concanavalin A and ultrastructural force microscopic studies of the complex formation. Preliminary efforts have been made to construct possible models to explain the nature of interaction within these assemblies. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.055