7-Ethyl-7-hydroxy-9-methoxy-7,8,9,12-tetrahydro-10H-cyclopenta-[6,7]indolizino[1,2-b]quinolin-10-one | 340268-13-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Ethyl-7-hydroxy-9-methoxy-7,8,9,12-tetrahydro-10H-cyclopenta-[6,7]indolizino[1,2-b]quinolin-10-one
• 英文别名: 5-Ethyl-5-hydroxy-7-methoxy-10,20-diazapentacyclo[10.8.0.02,10.04,8.014,19]icosa-1(20),2,4(8),12,14,16,18-heptaen-9-one
• CAS: 340268-13-5
• 化学式: C₂₁H₂₀N₂O₃
• 分子量: 348.401
• InChiKey: JDRFJQMAUMWJNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• New camptothecin analogue compounds
  申请人：——

  公开号：US20020077325A1

  公开（公告）日：2002-06-20

  Compound of formula (I): 1 wherein: n is 0, 1 or 2, R 1 , R 2 , R 3 , R 4 and R 5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH 2 ) p —NR a R b and —O—C(O)—N—R a R b , with p, R a and R b being as defined in the description, or two adjacent groups R 2 , R 3 , R 4 and R 5 together form a group —O—(CH 2 ) t —O, t being an integer from 1 to 3), R 60 , R 70n , R 80 and R 90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R 61 , R 71n , R 81 and R 91 represent a hydrogen atom , alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous diseases.

  化合物的式子（I）：其中：n为0、1或2，R1、R2、R3、R4和R5选择自氢、卤素、烷基、烯基、炔基、全氟烷基、环烷基、环烷基烷基、羟基、羟基烷基、烷氧基、烷氧基烷基、烷氧羰基、酰氧基、羧基、硝基、氰基、氨基羰基（可选择性取代），以及(CH2)p-NRaRb和-O-C(O)-N-RaRb这些基团，其中p、Ra和Rb如描述中所定义，或者相邻的两个基团R2、R3、R4和R5共同形成一个-O-( )t-O的基团，其中t为1到3的整数。R60、R70n、R80和R90代表氢原子、羟基、烷氧基或描述中定义的O-(CO)-X或O-(CO)-NXW基团。R61、R71n、R81和R91代表氢原子、烷基、烯基或炔基，或者成对地共同形成键或环氧丙烷基团，或者两个基团共同形成一个羰基团。含有这些化合物的药品对于治疗癌症疾病是有用的。
• New campothecin analogue compounds
  申请人：——

  公开号：US20030105109A1

  公开（公告）日：2003-06-05

  Compound of formula (I): 1 wherein: n is 0, 1 or 2, R 1 represents (C 3 -C 11 )cycloalkyl or (C 3 -C 11 )cycloalkylalkyl, R 2 , R 3 , R 4 and R 5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH 2 ) p —N a R b and —O—C(O)—N—R a R b , with p, R a and R b being as defined in the description, or two adjacent groups R 2 , R 3 , R 4 and R 5 together form a group —O—(CH 2 ) t —O, t being an integer from 1 to 3, R 60 , R 70n , R 80 and R 90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O—(CO)—X or O—(CO)—NXW group as defined in the description, R 61 , R 71n , R 81 , and R 91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group. and medicinal products containing the same are useful for the treatment of cancerous disesases.

  式(I)的化合物： 其中： n为0、1或2， R1代表(C3-C11)环烷基或(C3-C11)环烷基烷基， R2、R3、R4和R5选择自氢、卤素、烷基、烯基、炔基、全卤烷基、环烷基、环烷基烷基、羟基、羟基烷基、烷氧基、烷氧基烷基、烷氧羰基、酰氧基、羧基、硝基、氰基、氨基羰基（可选地取代）和(CH2)p—NaRb和—O—C(O)—N—RaRb基团，其中p、Ra和Rb如描述中定义，或者相邻的两个基团R2、R3、R4和R5组成—O—( )t—O基团，其中t为1到3的整数， R60、R70n、R80和R90代表氢原子、羟基、烷氧基，或者如描述中所定义的O—(CO)—X或O—(CO)—NXW基团， R61、R71n、R81和R91代表氢原子、烷基、烯基或炔基，或成对地共同形成键或环氧基团，或两个基团共同形成氧基团。 含有该化合物的药物对治疗癌症有用。
• US6509345B2
  申请人：——

  公开号：US6509345B2

  公开（公告）日：2003-01-21
• US6699876B2
  申请人：——

  公开号：US6699876B2

  公开（公告）日：2004-03-02