| 1561049-12-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1561049-12-4
• 化学式: C₅₀H₆₈O₁₅
• 分子量: 909.081
• InChiKey: PVTKURUGIIYPCC-HIBZIPOQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.58
• 重原子数：
  65.0
• 可旋转键数：
  17.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  149.45
• 氢给体数：
  1.0
• 氢受体数：
  15.0

反应信息

• 作为产物：
  描述：

  在 吡啶 、 sodium hydride 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 mineral oil 为溶剂， 反应 24.67h， 生成
  参考文献：
  名称：

  Direct Synthesis of 2-Deoxy-β-Glycosides via Anomeric O-Alkylation with Secondary Electrophiles

  摘要：

  An approach for direct synthesis of biologically significant 2-deoxy-beta-glycosides has been developed via O-alkylation of a variety of 2-deoxy-sugar-derived anomeric alkoxides using challenging secondary triflates as electrophiles. It was found a free hydroxyl group at C3 of the 2-deoxy-sugar-derived lactols is required in order to achieve synthetically efficient yields. This method has also been applied to the convergent synthesis of a 2-deoxy-beta-tetrasaccharide.

  DOI：

  10.1021/ja4116956