6'-O-methylsucrose | 59001-35-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6'-O-methylsucrose
• 英文别名: (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2-(hydroxymethyl)-5-(methoxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 59001-35-3
• 化学式: C₁₃H₂₄O₁₁
• 分子量: 356.327
• InChiKey: KWIDMMUHSFLNTP-WSPRHHJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  179
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  硫酸二甲酯 、 蔗糖 在 sodium hydroxide 作用下， 反应 1.0h， 生成 6'-O-methylsucrose 、 4'-O-methylsucrose 、 2-O-methylsucrose 、 6-O-methylsucrose
  参考文献：
  名称：

  单邻甲基蔗糖的碱性降解研究

  摘要：

  摘要研究了单-O-甲基蔗糖混合物的碱降解。混合物的某些组分以与蔗糖相似的方式相对快速地降解，但是1'-和3'-O-甲基蔗糖的降解非常缓慢。建议蔗糖的碱性降解通过两个初始的竞争性速率确定步骤发生，每个步骤都涉及SN icB机制。这些反应涉及在C-1被1'-和3'-氧阴离子取代，分别产生1-和3-O-α-d-吡喃葡萄糖基-d-果糖。6'-氧阴离子的类似取代也可能在很小程度上发生。内部取代反应的产物对碱极其敏感，并且主要被降解为乳酸和d-葡萄糖基糖精酸。

  DOI：

  10.1016/s0008-6215(00)85609-8

文献信息

• COMPOSITION AND METHOD FOR CANCER TREATMENT AND PREVENTION
  申请人：Liao Heather H.

  公开号：US20080261898A1

  公开（公告）日：2008-10-23

  Compounds, compositions, methods and kits are provided for treating, reducing the risk of, or preventing diseases and/or conditions, such as diseases associated with angiogenesis and/or abnormal cell proliferation, such as cancer. Compounds of the present invention have antiangiogenic and anti-cancer activity with minimum toxic effects on normal cells. Methods for preparing and manufacturing the compounds and pharmaceutical compositions are also provided.

  提供了用于治疗、减少风险或预防与血管生成和/或异常细胞增殖有关的疾病和/或疾病的化合物、组合物、方法和试剂盒，如癌症。本发明的化合物具有抗血管生成和抗癌活性，对正常细胞的毒性作用最小。还提供了制备和生产这些化合物及药物组合物的方法。
• Pyrone analogs for therapeutic treatment
  申请人：Robbins Wendye

  公开号：US20100189653A1

  公开（公告）日：2010-07-29

  Methods are described for the treatment and prevention of metabolic disorders or other diseases by administering a pyrone analog or a derivative thereof. Methods are also described for the treatment and prevention of metabolic disorders and other diseases by administering a pyrone analog, or a derivative thereof, in combination with one or more additional agents such as, for example, lipid lowering agents or glucose lowering agents. Methods are described for the modulation of lipid transporter activity to increase the efflux of lipid from a physiological compartment into an external environment. Methods disclosed herein may be used to assess treatment or prevention of a metabolic disorder following administration of a pyrone analog or a derivative thereof.

  本文介绍了使用吡喃类似物或其衍生物治疗和预防代谢性疾病或其他疾病的方法。本文还介绍了使用吡喃类似物或其衍生物与一个或多个其他药剂（例如，降脂药或降糖药）联合使用治疗和预防代谢性疾病和其他疾病的方法。本文还介绍了调节脂质转运蛋白活性以增加生理隔室中脂质向外部环境排出的方法。本文所披露的方法可用于评估使用吡喃类似物或其衍生物后治疗或预防代谢性疾病的效果。
• PHOSPHORYLATED AND PHOSPHONATED PYRONE ANALOGS FOR THERAPEUTIC TREATMENT
  申请人：Lee May Dean-Ming

  公开号：US20100297020A1

  公开（公告）日：2010-11-25

  Methods are described for the treatment and prevention of metabolic disorders or other diseases by administering a pyrone analog or a derivative thereof. Methods are also described for the treatment and prevention of metabolic disorders and other diseases by administering a pyrone analog, or a derivative thereof, in combination with one or more additional agents such as, for example, lipid lowering agents or glucose lowering agents. Methods are described for the modulation of lipid transporter activity to increase the efflux of lipid from a physiological compartment into an external environment. Methods disclosed herein may be used to assess treatment or prevention of a metabolic disorder following administration of a pyrone analog or a derivative thereof.

  本文描述了通过给予吡喃类似物或其衍生物的方法来治疗和预防代谢性疾病或其他疾病。还描述了通过给予吡喃类似物或其衍生物与一个或多个额外的药物如降脂药或降糖药组合的方法来治疗和预防代谢性疾病和其他疾病。本文还描述了调节脂质转运蛋白活性以增加生理区域中脂质向外部环境的外流的方法。本文所披露的方法可用于评估在给予吡喃类似物或其衍生物后治疗或预防代谢性疾病的效果。
• METHODS AND COMPOSITIONS FOR TREATING PAIN
  申请人：Robbins Wendye

  公开号：US20070087977A1

  公开（公告）日：2007-04-19

  Methods and compositions are described for the modulation of central nervous system and/or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compounds from physiological compartments, including central nervous system and fetal compartments.
• Methods and Compositions for Therapeutic Treatment
  申请人：Robbins Wendye

  公开号：US20080161248A1

  公开（公告）日：2008-07-03

  Methods and compositions are described for the modulation of central nervous system and/or fetal effects of calcineurin inhibitors. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of calcineurin inhibitors out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at Blood-Tissue, blood-CSF and placental-maternal barriers to increase the efflux of calcineurin inhibitor from physiological compartments, including central nervous system and fetal compartments.