2-deoxy-2-<(R)-3-tetradecanoyloxytetradecanamido>-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-6-O-(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosyl)-4-O-phosphono-D-glucopyranose | 113757-78-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-2-<(R)-3-tetradecanoyloxytetradecanamido>-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-6-O-(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosyl)-4-O-phosphono-D-glucopyranose
• CAS: 113757-78-1
• 化学式: C₈₁H₁₄₃N₂O₂₆P
• 分子量: 1592.0
• InChiKey: OEPRTLWWZARFQS-QGMSGTORSA-N

物化性质

• 熔点：
  41-45 °C
• 密度：
  1.16±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  benzyl 2-deoxy-2-<(R)-3-tetradecanoyloxytetradecanamido>-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-6-O-(benzyl-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosyl)-4-O-diphenylphosphono-β-D-glucopyranoside 在 platinum(IV) oxide 、 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以23%的产率得到2-deoxy-2-<(R)-3-tetradecanoyloxytetradecanamido>-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-6-O-(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosyl)-4-O-phosphono-D-glucopyranose
  参考文献：
  名称：

  Neuraminic acid and related compounds. I. Syntheses of biologically active 4',7',8',9'-tetra-O-acetyl-sialyl- and sialyl-(.ALPHA.2-6)-D-glucosamine-4-phosphate analogues of lipid A.

  摘要：

  本文描述了脂A的新型四乙酰唾液酸和唾液酸（α2-6）-D-葡萄糖胺-4-磷酸类似物的合成，其中唾液酸取代了3-脱氧-D-甘露-2-辛酮糖醛酸（KDO）。对生物活性的初步检查表明，两种合成的二糖具有微弱的促有丝分裂活性。

  DOI：

  10.1248/cpb.36.1772