| 1192815-46-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1192815-46-5
• 化学式: C₄₁H₇₄O₉SSi₂
• 分子量: 799.27
• InChiKey: NDLUBQPUPZXYOM-UXXOMSTCSA-N

反应信息

• 作为产物：
  描述：

  、 在 chromium dichloride 、 锰 、 二氯二茂锆 、 di-μ-chloro-bis[chloro(4,7-dimethyl-1,10-phenanthroline)]nickel(II) 、 N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide 、 1,8-双二甲氨基萘 、 lithium chloride 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Toolbox Approach to the Search for Effective Ligands for Catalytic Asymmetric Cr-Mediated Coupling Reactions

  摘要：

  Chromium catalysts derived from chiral sulfonamides represented by A effect the couplings of aldehydes with vinyl, allyl, or alkyl halides. With three distinct sites for structural modification, A affords access to a structurally diverse pool of chiral sulfonamides. The Cr catalysts derived from these sulfonamides exhibit a broad range of catalyst-substrate matching profiles. A strategy is presented to search for a satisfactory chiral sulfonamide for a given substrate. In order to demonstrate the generality and effectiveness of this approach, five diverse C-C bond-forming cases have been selected from the halichondrin synthesis. For each of the cases, two ligands have been deliberately searched for, to induce the formation of (R)and (S)-alcohols, respectively, at the arbitrarily chosen efficiency level of ">= 80% yield with >= 20:1 stereoselectivity in the presence of <= 20 mol % of a Cr catalyst". For 9 out of the 10 cases studied, a satisfactory catalyst has been found within this pool of sulfonamides. Even for the remaining case, a Cr catalyst inducing stereoselectivity up to 8:1 has been identified.

  DOI：

  10.1021/ja905843e