3,3'-dioxo-3,3'-(2,4,6-trimethyl-m-phenylene)-di-propionitrile | 856205-22-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3'-dioxo-3,3'-(2,4,6-trimethyl-m-phenylene)-di-propionitrile
• 英文别名: 3,3'-dioxo-3,3'-(2,4,6-trimethyl-m-phenylene)-di-propionitrile；3,3'-Dioxo-3,3'-(2,4,6-trimethyl-m-phenylen)-di-propionitril；1,3,5-Trimethyl-2,4-bis-cyanacetyl-benzol
• CAS: 856205-22-6
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.288
• InChiKey: QXRJQDYIEIVYKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81.72
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3,3'-dioxo-3,3'-(2,4,6-trimethyl-m-phenylene)-di-propionitrile 在 sodium hydroxide 、 sodium hypobromide 作用下， 生成 2,2,2',2'-tetrabromo-3,3'-dioxo-3,3'-(2,4,6-trimethyl-m-phenylene)-di-propionitrile
  参考文献：
  名称：

  Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 diabetes mellitus

  摘要：

  Autoimmune thyroiditis is often associated with Type 1 diabetes mellitus (T1DM). In non-obese adult-onset diabetes diagnosed initially as Type 2 diabetes mellitus (T2DM), there is a proportion of cases with so far undiagnosed T1DM. The objective of this study was to estimate the frequency of autoimmune thyroiditis (AT) among non-obese (BMI <30.0 kg/m2) patients with T2DM and to compare the frequency of AT in subgroups of patients according to the presence of glutamic acid decarboxylase antibodies (GADA), insulin requirement, and post-breakfast C-peptide levels. The study included 118 adult patients (55 men and 63 women) with the initial diagnosis of T2DM and age at the onset of diabetes > 35 yr. Median of age was 66 yr (range 39-82), and median duration of diabetes was 9 (range 1-27) yr. AT was diagnosed using thyroid peroxidase antibodies, TG-antibodies, US and TSH levels. Nineteen per cent of the subjects were found to have AT, and the frequency of AT did not significantly differ between the groups of GADA+ and GADA- subjects. There was no difference in the frequency of AT between the group treated with hypoglycemic agents and/or diet and the group requiring insulin. The frequency of AT was higher in the group with post-breakfast C-peptide levels < or = 0.8 nmol/l compared to the group with post-breakfast C-peptide levels > 0.8 nmol/l (37% vs 16%), however the group with post-breakfast C-peptide levels < or = 0.8 nmol/l had longer duration of diabetes.

  DOI：

  10.1007/bf03345512
• 作为产物：
  描述：

  2,4-bis-chloroacetyl-1,3,5-trimethyl-benzene 、 氰化钾 在 乙醇 作用下， 生成 3,3'-dioxo-3,3'-(2,4,6-trimethyl-m-phenylene)-di-propionitrile
  参考文献：
  名称：

  Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 diabetes mellitus

  摘要：

  Autoimmune thyroiditis is often associated with Type 1 diabetes mellitus (T1DM). In non-obese adult-onset diabetes diagnosed initially as Type 2 diabetes mellitus (T2DM), there is a proportion of cases with so far undiagnosed T1DM. The objective of this study was to estimate the frequency of autoimmune thyroiditis (AT) among non-obese (BMI <30.0 kg/m2) patients with T2DM and to compare the frequency of AT in subgroups of patients according to the presence of glutamic acid decarboxylase antibodies (GADA), insulin requirement, and post-breakfast C-peptide levels. The study included 118 adult patients (55 men and 63 women) with the initial diagnosis of T2DM and age at the onset of diabetes > 35 yr. Median of age was 66 yr (range 39-82), and median duration of diabetes was 9 (range 1-27) yr. AT was diagnosed using thyroid peroxidase antibodies, TG-antibodies, US and TSH levels. Nineteen per cent of the subjects were found to have AT, and the frequency of AT did not significantly differ between the groups of GADA+ and GADA- subjects. There was no difference in the frequency of AT between the group treated with hypoglycemic agents and/or diet and the group requiring insulin. The frequency of AT was higher in the group with post-breakfast C-peptide levels < or = 0.8 nmol/l compared to the group with post-breakfast C-peptide levels > 0.8 nmol/l (37% vs 16%), however the group with post-breakfast C-peptide levels < or = 0.8 nmol/l had longer duration of diabetes.

  DOI：

  10.1007/bf03345512