Unii-76dyp9H6PY | 1633931-74-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Unii-76dyp9H6PY
• 英文别名: (E)-N-(2-methylpropyl)-3-[7-(trifluoromethyl)-1,3-benzodioxol-5-yl]prop-2-enamide
• CAS: 1633931-74-4
• 化学式: C₁₅H₁₆F₃NO₃
• 分子量: 315.29
• InChiKey: VAZLSVGNKRGDCR-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Application of substituted cinnamamide derivatives in preparation of anti-anxiety medication
  申请人：TASLY PHARMACEUTICAL GROUP CO., LTD.

  公开号：US10874636B2

  公开（公告）日：2020-12-29

  Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R1 is —H, —OH, —F, —Cl, —Br, —I, —OCH3, —OCF3, —OCHF2, —OCH2F, —CF3, —CHF2, —CH2F, —CH3, —CH3CH2, —CF3CH2, —CN, —NO2, —NH2 or —COOR5; R2 is H, C1-C10 linear alkyl, C3-C10 branched alkyl, C3-C10 cyclic alkyl, C1-C10 hydroxyalkyl or a N-substituted piperazine-derived group; or R2 is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.

  公开了取代肉桂酰胺衍生物在制备抗焦虑药物中的应用，取代肉桂酰胺衍生物是具有式(I)结构的化合物或其药学上可接受的盐、 其中，R1 是-H、-OH、-F、-Cl、-Br、-I、-O 、-O 、-O 、-O 、-CF3、-CHF2、-CH2F、-CH3、- CH2、- CH2、-CN、-NO2、-NH2 或-COOR5； R2 是 H、C1-C10 直链烷基、C3-C10 支链烷基、C3-C10 环烷基、C1-C10 羟基烷基或 N-取代的哌嗪衍生基团；或 R2 是与相邻 Y 形成四氢吡咯基团、哌啶基团或环己胺基的基团。
• SUBSTITUTED CINNAMAMIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
  申请人：Tasly Pharmaceutical Group Co., Ltd.

  公开号：EP2725018B1

  公开（公告）日：2017-04-19
• APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS
  申请人：Tasly Pharmaceutical Group Co., Ltd.

  公开号：EP3409664B1

  公开（公告）日：2021-01-06
• APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATION
  申请人：TASLY PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20190046500A1

  公开（公告）日：2019-02-14

  Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R 1 is —H, —OH, —F, —Cl, —Br, —I, —OCH 3 , —OCF 3 , —OCHF 2 , —OCH 2 F, —CF 3 , —CHF 2 , —CH 2 F, —CH 3 , —CH 3 CH 2 , —CF 3 CH 2 , —CN, —NO 2 , —NH 2 or —COOR 5 ; R2 is H, C 1 -C 10 linear alkyl, C 3 -C 10 branched alkyl, C 3 -C 10 cyclic alkyl, C 1 -C 10 hydroxyalkyl or a N-substituted piperazine-derived group; or R 2 is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.