7-Octenoic acid, 5,6-dihydroxy-8-(2-((1E,3R)-3-hydroxy-1-octenyl)phenyl)-, (5S,6R,7E)- | 864516-86-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: 7-Octenoic acid, 5,6-dihydroxy-8-(2-((1E,3R)-3-hydroxy-1-octenyl)phenyl)-, (5S,6R,7E)-
• 英文别名: (E,5S,6R)-5,6-dihydroxy-8-[2-[(E,3R)-3-hydroxyoct-1-enyl]phenyl]oct-7-enoic acid
• CAS: 864516-86-9
• 化学式: C₂₂H₃₂O₅
• 分子量: 376.5
• InChiKey: HEDVTGFTYROYFE-RREUNBNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] SYNTHESIS OF PRO-RESOLVING ANALOGS AND COMPOSITIONS THEREFOR<br/>[FR] SYNTHÈSE D'ANALOGUES DE PRO-RÉSOLUTION ET COMPOSITIONS ASSOCIÉES
  申请人：NOCENDRA INC

  公开号：WO2021021552A1

  公开（公告）日：2021-02-04

  This disclosure relates to methods of synthesizing certain lipoxin analogs (e.g., lipoxin mimetics, etc.) and pharmaceutical compositions comprising these pro-resolving compounds. Methods of administering the lipoxin mimetics (e.g., lipoxin A4 mimetics, lipoxin B4 mimetics, etc.) to patients in need thereof are also provided.

  本披露涉及合成某些脂肪酸类似物（例如，脂肪酸类似物等）和含有这些促进解决化合物的药物组合物的方法。还提供了向需要的患者施用脂肪酸类似物（例如，脂肪酸A4类似物，脂肪酸B4类似物等）的方法。
• LIPOXIN ANALOGS AND METHODS FOR THE TREATMENT OF PERIODONTAL DISEASE
  申请人：Van Dyke Thomas E.

  公开号：US20110064677A1

  公开（公告）日：2011-03-17

  This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
• US8093417B2
  申请人：——

  公开号：US8093417B2

  公开（公告）日：2012-01-10