N-[(4-Methoxyphenyl)methyl]-2-phenylquinoline-8-carboxamide | 655222-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(4-Methoxyphenyl)methyl]-2-phenylquinoline-8-carboxamide
• CAS: 655222-70-1
• 化学式: C₂₄H₂₀N₂O₂
• 分子量: 368.4
• InChiKey: IEEQOSQXHLIKBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：GlaxoSmithKline LLC

  公开号：EP2273992B1

  公开（公告）日：2016-05-25
• [EN] QUENOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS<br/>[FR] QUINOLÉINES ET ANALOGUES APPARENTÉS EN TANT QUE MODULATEURS DE SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2009134973A1

  公开（公告）日：2009-11-05

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.