tert-butyl N-[(2-methoxypyridin-3-yl)methyl]carbamate | 334018-92-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl N-[(2-methoxypyridin-3-yl)methyl]carbamate
• CAS: 334018-92-7
• 化学式: C₁₂H₁₈N₂O₃
• 分子量: 238.28
• InChiKey: VYJCXTILTCBQIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(azidomethyl)-2-methoxypyridine 、 tert-butyl dicarbonate 、 氢气 在 palladium-carbon silica gel 、 ethyl acetate n-hexane 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 以6.84 g of tertiary butyl N-[(2-methoxy-3-pyridyl)methyl]carbamate was obtained的产率得到tert-butyl N-[(2-methoxypyridin-3-yl)methyl]carbamate
  参考文献：
  名称：

  Carboxylic acid derivatives and drugs containing the same

  摘要：

  化合物的一般式（I）的新型羧酸衍生物，其盐、酯或水合物，可用作胰岛素抵抗改善剂；以及含有该衍生物作为活性成分的药物。在所述的公式中，R1是氢、羟基、烷基或类似物；L是单键、双键、烷基或类似物；M是单键、烷基或类似物；T是单键、烷基或类似物；W是羧基、—CON（RW1）RW2或类似物；表示单键或双键；X是氧、烯基烷基或类似物；Y是芳香族碳氢基团，可以包含杂原子或类似物；Z是芳香族碳氢基团，可以包含杂原子。

  公开号：

  US06884821B1

文献信息

• [EN] COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR<br/>[FR] COMPOSÉS ET MÉTHODES DE MODULATION DES KINASES ET LEURS INDICATIONS D'EMPLOI
  申请人：PLEXXIKON INC

  公开号：WO2011057022A1

  公开（公告）日：2011-05-12

  Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthiritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.
• Carboxylic acid derivatives and drugs containing the same
  申请人：Shinoda Masanobu

  公开号：US06884821B1

  公开（公告）日：2005-04-26

  Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R 1 is hydrogen, hydroxyl, alkyl, or the like; L is a single bond, a double bond, alkylene, or the like; M is a single bond, alkylene, or the like; T is a single bond, alkylene, or the like; W is carboxyl, —CON(R W1 )R W2 , or the like; represents a single or double bond; X is oxygen, alkenylene, or the like; Y is an aromatic hydrocarbon group which may contain a heteroatom, or the like; and Z is an aromatic hydrocarbon group which may contain a heteroatom.

  化合物的一般式（I）的新型羧酸衍生物，其盐、酯或水合物，可用作胰岛素抵抗改善剂；以及含有该衍生物作为活性成分的药物。在所述的公式中，R1是氢、羟基、烷基或类似物；L是单键、双键、烷基或类似物；M是单键、烷基或类似物；T是单键、烷基或类似物；W是羧基、—CON（RW1）RW2或类似物；表示单键或双键；X是氧、烯基烷基或类似物；Y是芳香族碳氢基团，可以包含杂原子或类似物；Z是芳香族碳氢基团，可以包含杂原子。