2-{3-{4-[3-(8-hydroxy-6-oxo-6H-imidazo[4,5,1-de]acridin-5-yl)aminopropyl]-piperazin-1-yl}propyl}-5-amino-1H-benz[de]isoquinoline-1,3(2H)-dione | 359630-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-{3-{4-[3-(8-hydroxy-6-oxo-6H-imidazo[4,5,1-de]acridin-5-yl)aminopropyl]-piperazin-1-yl}propyl}-5-amino-1H-benz[de]isoquinoline-1,3(2H)-dione
• 英文别名: 5-Amino-2-[3-[4-[3-[(5-hydroxy-8-oxo-1,14-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-2(7),3,5,9,11,13(16),14-heptaen-10-yl)amino]propyl]piperazin-1-yl]propyl]benzo[de]isoquinoline-1,3-dione
• CAS: 359630-74-3
• 化学式: C₃₆H₃₅N₇O₄
• 分子量: 629.718
• InChiKey: ZBGNGWUHJAEZHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  47
• 可旋转键数：
  9
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• 1,8-NAPHTHALIMIDE IMIDAZO{4,5,1-DE}ACRIDONES WITH ANTI-TUMOR ACTIVITY
  申请人：——

  公开号：US20030203916A1

  公开（公告）日：2003-10-30

  The invention provides imidazoacridone compounds of general formula (1) which have cytotoxic and anti-tumor activity. The invention also provides methods of preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirably high levels of cell proliferation. The compounds of the invention are also expected to have utility as research tools. 1

  该发明提供了一般式（1）的咪唑喹啉酮化合物，具有细胞毒性和抗肿瘤活性。该发明还提供了制备这些化合物的方法，以及利用这些化合物治疗癌症或其他哺乳动物疾病的方法，这些疾病具有细胞增殖水平过高的特征。该发明的化合物还有望作为研究工具具有实用性。
• 1,8-NAPHTHALIMIDE IMIDAZO 4,5,1- i de /i ]ACRIDONES WITH ANTI-TUMOR ACTIVITY
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP1265898B1

  公开（公告）日：2003-09-24
• COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS
  申请人：BROWN Dennis M.

  公开号：US20160067241A1

  公开（公告）日：2016-03-10

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to naphthalimides such as amonafide or analogs, derivatives, or prodrugs thereof.
• US6664263B2
  申请人：——

  公开号：US6664263B2

  公开（公告）日：2003-12-16