O-3-[(2R)-2,6-dihydroxy-2-(2'-cyclohexaneamino-2'-oxoethyl)-6-methylheptanoyl]cephalotaxine | 1423218-62-5

分子结构分类

有机化合物 - 生物碱及其衍生物 - 三尖杉生物碱

中文名称

——

中文别名

——

英文名称

O-3-[(2R)-2,6-dihydroxy-2-(2'-cyclohexaneamino-2'-oxoethyl)-6-methylheptanoyl]cephalotaxine

英文别名

O-3-[(2R)-2,6-dihydroxy-2-(2’-cyclohexaneamino-2’-oxoethyl)-6-methylheptanoyl]cephalotaxine；[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] (2R)-2-[2-(cyclohexylamino)-2-oxoethyl]-2,6-dihydroxy-6-methylheptanoate

O-3-[(2R)-2,6-dihydroxy-2-(2'-cyclohexaneamino-2'-oxoethyl)-6-methylheptanoyl]cephalotaxine化学式

CAS

1423218-62-5

化学式

C₃₄H₄₈N₂O₈

mdl

——

分子量

612.764

InChiKey

OODYCYQXUVTNHI-PZNHDNIZSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

2.6
重原子数：

44
可旋转键数：

11
环数：

6.0
sp3杂化的碳原子比例：

0.71
拓扑面积：

127
氢给体数：

3
氢受体数：

9

文献信息

AMINATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

申请人：Rong Frank

公开号：US20140206669A1

公开（公告）日：2014-07-24

The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel aminated homoharringtonine derivatives of formula (I) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

本发明属于天然药物和药学化学领域，具体涉及公式（I）的新型氨基化的同蒿芦丁衍生物及其药学上可接受的盐，制备这些化合物的方法，含有这些化合物的组合物以及它们在制备抗肿瘤药物方面的用途。
US9676789B2

申请人：——

公开号：US9676789B2

公开（公告）日：2017-06-13

同类化合物

高三尖杉酯碱酰胺高三尖杉酯碱氧桥三尖杉碱异三尖杉酯碱双(去甲基)-脱氧三尖杉酯碱去甲基三尖杉酮碱去氧哈林通碱乙酰三尖杉碱三尖杉酯碱三尖杉酯碱三尖杉碱 4-羟基三尖杉碱 4'-去甲基高三尖杉酯碱 (1S,3aR)-1,5,6,8,9,14bbeta-六氢-2-甲氧基-4H-环戊并[a][1,3]二氧杂环戊并[4,5-H]吡咯并[2,1-b][3]苯并氮杂卓-1alpha,9alpha-二醇 (-)-脱水三尖杉酯碱 (2S,3R,4S,5S,7R)-2,3-dihydroxy-7-methyl-cephalotaxan-8-one (2R,3S,4S,5S)-2,3-dihydroxy-8-oxocephalotaxane (+/-)-D-homocephalotaxine Desmethyldiacetyl-cephalotaxin (3aα,4S*,10β,15bβ,15cα)-(+/-)-10-acetoxy-3a,4,6,7,9,10,15b,15c-octahydro-2,2-dimethyl-5H-<1,3>dioxolo<4,5-h>-1,3-dioxolo<4,5>cyclopenta<1,2-a>pyrrolo<2,1-b><3>benzazepine Cephalotaxyl 6,6-dimethyl-5,6-dihydropyran-1-carboxylate 3t-phenyl-acrylic acid (3aR)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl ester 6-O-(4-methylimidazole-3-carbonyl)2,6-diacetylhomoharringtonine 6-O-(2-chloropyridin-3-carbonyl)2,6-diacetylhomoharringtonine (Ξ)-methylsuccinic acid 1-((3aR)-2-methoxy-(3arC⁴,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl) ester 4-methyl ester 6-O-(phenylacetyl)2,6-diacetylhomoharringtonine 6-O-(furan-2-carbonyl)2,6-diacetylhomoharringtonine succinic acid (3aR)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl ester methyl ester O-3-[(2R)-2,6-dihydroxy-2-(2'-cyclohexaneamino-2'-oxoethyl)-6-methylheptanoyl]cephalotaxine (2R,7R)-17,19-dioxa-11-azapentacyclo[12.7.0.02,7.07,11.016,20]henicosa-1(21),4,12,14,16(20)-pentaen-10-one Acetic acid 6-((1aR,2aS,5aR,6S,6aS)-5-methyl-4-oxo-octahydro-1-oxa-5-aza-cyclopropa[f]inden-6-yl)-benzo[1,3]dioxol-5-ylmethyl ester (Ξ)-(3-methyl-butyl)-succinic acid 1-((3aR)-2-methoxy-(3arC⁴,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl) ester 4-methyl ester 1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-[4-methyl-4-(4-methyl-1,3-thiazole-5-carbonyl)oxypentyl]-2-(4-methyl-1,3-thiazole-5-carbonyl)oxybutanedioate 3,8-dioxocephalotax-1-ene furan-3,4-dicarboxylic acid (3aR)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl ester methyl ester 2α,3α-dihydroxycephalotaxan-8-one 2,3-dehydrocephalotaxan-8-one 1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-[4-(cyclohexanecarbonyloxy)-4-methylpentyl]-2-hydroxybutanedioate 2α,3α-epoxycephalotaxan-8-one [(2S,3R,4S,6S)-3-acetyloxy-9-oxo-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),13,15(19)-trien-4-yl] acetate (3-methyl-butyl)-butenedioic acid 1-((3aR)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl) ester 4-methyl ester benzyl ((2S,3S,3aR)-2,3-dihydroxy-2,3,5,6,8,9-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) carbonate 3t-(4-nitro-phenyl)-acrylic acid (3aR)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl ester (2R,3S,4S,5S)-2-(tert-butyldimethylsililoxy)-3-hydroxy-8-oxocephalotaxane

O-3-[(2R)-2,6-dihydroxy-2-(2'-cyclohexaneamino-2'-oxoethyl)-6-methylheptanoyl]cephalotaxine | 1423218-62-5

分子结构分类

计算性质

文献信息

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