8-chloro-2,3,5,6,6a,7,8,9,10,10a-decahydro-1,5,6-trimethyl-(1H)-benzo[c]quinolizin-3-one | 868829-87-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-chloro-2,3,5,6,6a,7,8,9,10,10a-decahydro-1,5,6-trimethyl-(1H)-benzo[c]quinolizin-3-one
• 英文别名: 8-Chloro-1,5,6-trimethyl-1,2,5,6,6a,7,8,9,10,10a-decahydrobenzo[f]quinolizin-3-one
• CAS: 868829-87-2
• 化学式: C₁₆H₂₄ClNO
• 分子量: 281.826
• InChiKey: AEOWOUMGZSQHQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
  申请人：APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

  公开号：EP0926148A1

  公开（公告）日：1999-06-30

  The present invention refers to benzo[c]quinolizines derivatives, fully and partially saturated, having formula (I) and their pharmaceutically acceptable salts which proves useful for pharmaceutical and agricultural use being capable of inhibiting the 5α-reductase enzyme either selectively in respect of 5αR-I and 5αR-II or on both the iso-enzymes. Compounds (1) can be used to regulate growth and act as herbicides, or to treat acne, baldness, prostatic cancer and prostatic hypertrophy.

  本发明涉及苯并[c]喹啉衍生物，完全和部分饱和，其具有公式（I）及其药学上可接受的盐，对医药和农业用途有用，能够选择性地抑制5α-还原酶酶，无论是对于5αR-I和5αR-II还是对于两种亚型的酶。化合物（1）可用于调节生长并作为除草剂，或用于治疗痤疮，脱发，前列腺癌和前列腺肥大。
• BENZO(C)QUINOLIZINE DERIVATIVES AND THEIR USE AS 5 ALPHA-REDUCTASES INHIBITORS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1066284B1

  公开（公告）日：2005-08-31
• US6962925B1
  申请人：——

  公开号：US6962925B1

  公开（公告）日：2005-11-08