4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[1,5-a]pyridin-3-yl]-quinoline-7-carboxylic acid[3-(4-methyl-piperazin-1-yl)-propyl]-amide | 676344-34-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[2-(6-methyl-pyridin-2-yl)-pyrazolo[1,5-a]pyridin-3-yl]-quinoline-7-carboxylic acid[3-(4-methyl-piperazin-1-yl)-propyl]-amide
• 英文别名: N-[3-(4-methylpiperazin-1-yl)propyl]-4-[2-(6-methylpyridin-2-yl)pyrazolo[1,5-a]pyridin-3-yl]quinoline-7-carboxamide
• CAS: 676344-34-6
• 化学式: C₃₁H₃₃N₇O
• 分子量: 519.649
• InChiKey: SGZUVRBZNUXBAL-UHFFFAOYSA-N

物化性质

• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  78.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Novel pyrazolopyridine derivatives as pharmaceutical agents
  申请人：Beight Wade Douglas

  公开号：US20050222197A1

  公开（公告）日：2005-10-06

  Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.

  本发明揭示了一种新型吡唑吡啶衍生物化合物，其作为药物代理使用，特别是其作为TGF-beta信号传导抑制剂在治疗癌症和其他受TGF beta影响的疾病状态中的应用。
• EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
  申请人：Ichida Justin

  公开号：US20120021519A1

  公开（公告）日：2012-01-26

  The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.
• US7365066B2
  申请人：——

  公开号：US7365066B2

  公开（公告）日：2008-04-29