2-amino-2,6-dideoxy-D-glucose | 527-37-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-2,6-dideoxy-D-glucose
• 英文别名: D-quinovosamine；1-Amino-2,6-dideoxy-D-glucopyranose；(3R,4R,5S,6R)-3-amino-6-methyloxane-2,4,5-triol
• CAS: 527-37-7
• 化学式: C₆H₁₃NO₄
• 分子量: 163.174
• InChiKey: TVTGZVYLUHVBAJ-IVMDWMLBSA-N

物化性质

• 沸点：
  361.5±42.0 °C(Predicted)
• 密度：
  1.406±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.9
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 sodium nitrite 、 三氟乙酸 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 4.0h， 生成 2-amino-2,6-dideoxy-D-glucose
  参考文献：
  名称：

  Structure of a new ribitol teichoic acid-like O-polysaccharide of a serologically separate Proteus vulgaris strain, TG 276-1, classified into a new Proteus serogroup O53

  摘要：

  An unusual ribitol teichoic acid-like O-polysaccharide was isolated by mild acid degradation of the lipopolysaccharide from a previously non-classified Proteus viularis strain TG 276-1. Structural studies using chemical analyses and 2D H-1 and(13)C NMR spectroscopy showed that the polysaccharide is a zwitterionic polymer with a repeating unit containing 2-acetamido-4amino-2,4,6-trideOXy- D -galactose (D-FucNAc4N) and two iD-ribitol phosphate (D-Rib-ol-5-P) residues and having the following structure:-> 3)-beta-D-FucpNAc4N-(1 -> 1)-D-Rib-ol-5-P-(O -> 1)-D-Rib-ol-5-P-(O ->,where the non-glycosylated ribitol residue is randomly mono-O-acetylated. Based on the unique 0-polysaccharide structure and the finding that the strain studied is serologically separate among Proteus bacteria, we propose to classify P. vulgaris strain TG 276-1 into a new Proteus serogroup, O53. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2007.05.036

文献信息

• ANTIBODY-DRUG CONJUGATE (ADC) AND METHOD FOR FORMING THE SAME
  申请人：Industrial Technology Research Institute

  公开号：US20170119902A1

  公开（公告）日：2017-05-04

  An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided. A-(L-D) p (I)

  提供了公式（I）的抗体药物结合物（ADC）或其药学上可接受的盐或溶剂。在公式（I）中，p是1到26的整数，A是抗体，而-（L-D）是连接-药物单元。L是具有糖肽的连接单元，D是药物单元。通过抗体的半胱氨酸残基将抗体与连接单元结合。还提供了一种形成抗体药物结合物（ADC）的方法。A-（L-D）p（I）
• [EN] AEROSOL GENERATION OR SMOKING SYSTEM, OR ELECTRONIC CIGARETTE AND DEVICE THEREOF<br/>[FR] SYSTÈME DE GÉNÉRATION D'AÉROSOL OU SYSTÈME À FUMER, OU CIGARETTE ÉLECTRONIQUE ET DISPOSITIF ASSOCIÉ<br/>[ZH] 一种气溶胶生成或烟雾化系统或电子烟及其装置
  申请人：ZHONG SHUGUANG

  公开号：WO2020239083A1

  公开（公告）日：2020-12-03

  一种气溶胶生成材料及使该气溶胶生成材料烟雾化或汽化或气雾化或气溶胶化的装置，该气溶胶生成材料包括含药学上可接受的烟碱盐及药学上可接受的气溶胶或烟雾生成剂的组合物Ⅰ及含药学上可接受的碱性比该烟碱更强的碱（其pKa值大于该烟碱的pKa值）及药学上可接受的气溶胶或烟雾生成剂的组合物Ⅱ，上述组合物Ⅰ及Ⅱ均以烟雾化态或汽化态或气雾态或气溶胶被使用者/消费者吸入。该气溶胶劲头足，生理满足感好，呛喉感低或无，刺激性低或无，过喉性好，烟碱生物利用率高，消费者使用感受良好。
• Hildesheim,J. et al., Israel Journal of Chemistry, 1970, vol. 8, p. P52
  作者：Hildesheim,J. et al.

  DOI：——

  日期：——
• ENZYMATIC METHOD FOR PREPARATION OF UDP-GLCNAC
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3874056A1

  公开（公告）日：2021-09-08
• COMPOUNDS, LINKER-DRUGS AND LIGAND-DRUG CONJUGATES
  申请人：Industrial Technology Research Institute

  公开号：US20180016300A1

  公开（公告）日：2018-01-18

  A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently, hydrogen, amino, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxylic acid, C1-C6 alkoxycarbonyl, C1-C6 amino, C1-C6 aminocarbonyl, C1-C6 alkyl, branched C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclic, aryl or heteroaryl, provided at least one of R1 and R3 is an amino group. A linker-drug and a ligand-drug conjugate including the compound are also provided.