4'-((4-氯苯基)磺酰基)-[1,1'-联苯]-4-醇 | 30809-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4'-((4-氯苯基)磺酰基)-[1,1'-联苯]-4-醇
• 英文名称: 4'-<(4-Chlorophenyl)sulfonyl>biphenyl-4-ol
• 英文别名: 4-(4-chlorophenylsulphonyl)-4'-hydroxy biphenyl；[1,1'-Biphenyl]-4-ol, 4'-[(4-chlorophenyl)sulfonyl]-；4-[4-(4-chlorophenyl)sulfonylphenyl]phenol
• CAS: 30809-75-7
• 化学式: C₁₈H₁₃ClO₃S
• 分子量: 344.818
• InChiKey: MSMJUFPVLFLUKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温下，应保存于惰性气体中。

反应信息

• 作为反应物：
  描述：

  4'-((4-氯苯基)磺酰基)-[1,1'-联苯]-4-醇 在 四(三苯基膦)钯 甲醇 、 sodium hydride 、 碳酸氢钠 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 39.0h， 生成 4-(4-(2-hydroxyethylthio)phenyl)-4'-(4-(2-hydroxyethyloxy)phenyl)diphenyl sulfone
  参考文献：
  名称：

  OPTICAL ELEMENT COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT

  摘要：

  提供具有以下特征的光学材料有机化合物：折射率的色散特性（阿贝数（νd））和二次色散特性（θg,F）高，可见光区域的透射率高，色差校正功能性能高，其通用公式（1）或（2）表示。

  公开号：

  US20110288330A1
• 作为产物：
  描述：

  4,4'-二氯二苯砜 在 喹喔啉 、 三氟甲磺酸 、 potassium tert-butylate 、 甲苯 作用下， 以 氨 为溶剂， 反应 3.0h， 生成 4'-((4-氯苯基)磺酰基)-[1,1'-联苯]-4-醇
  参考文献：
  名称：

  Electrosynthesis of Unsymmetrical Polyaryls by a SRN1-Type Reaction

  摘要：

  Unsymmetrical polyaryls are electrosynthesized in liquid ammonia by a single-step S(RN)1 reaction in the presence of a redox mediator starting from aromatic halides and 2,6-di-tert-butyl phenoxide. With monoaryl halides activated by electron-withdrawing substituents (N of pyridyl or quinolyl, trifluoromethyl, cyano, sulfone, ester, ketone, alkyl sulfide, N+ of anilinium), biaryls are obtained in good yields (between 50 and 95%). The yields of ter- and quateraryls are lower (40% maximum). The reaction is extended to other ortho-disubstituted phenols. Elimination reactions of the tert-butyl groups from the products are achieved by a Friedel-Crafts reaction using either trifluoromethanesulfonic acid or aluminum trichloride as catalysts.

  DOI：

  10.1021/jo00095a024

文献信息

• Production of aromatic polyethers
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0010868A2

  公开（公告）日：1980-05-14

  Production of aromatic polyethers by reacting i) a mixture of a bisphenol and a dihalobenzenoid compound or ii) a halophenol, in which dihalobenzenoid compound or halophenol the halogen atoms are activated by ortho or para -SO2- or -CO- groups, with an alkali metal (bi)-carbonate, wherein the reaction is carried out in the absence of a solvent and in the presence of an infusible particulate support substance, preferably inorganic or polymeric, yielding a reaction medium in the form of a free-flowing powder by the end of the reaction.

  通过 i）双酚和二卤代苯化合物的混合物或 ii）卤代苯酚（其中二卤代苯化合物或卤代苯酚中的卤素原子被正对或对位 -SO2- 或 -CO- 基团活化）与碱金属（双）碳酸盐反应生产芳香族聚醚、其中，反应是在无溶剂且有可注入的颗粒支撑物质（最好是无机或聚合物）存在的情况下进行的，反应结束后，反应介质呈自由流动的粉末状。
• Process for the Preparation of Polyetherketones
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0182648A2

  公开（公告）日：1986-05-28

  Polyaryletherketones are prepared by polymerisation of a halogen-containing aryl ketone in the presence of a stoichiometric excess of a base and a copper salt. The halogen-containing aryl ketone may be 4-chloro-4'-hydroxybenzophenone. A basic copper salt may be used but the base used to provide the excess of base is an alkali metal hydroxide, carbonate or bicarbonate.

  多芳基醚酮是通过含卤芳基酮在过量的碱和铜盐的存在下发生聚合反应而制备的。 含卤芳基酮可以是 4-氯-4'-羟基二苯甲酮。 可以使用碱式铜盐，但提供过量碱的碱是碱金属氢氧化物、碳酸盐或碳酸氢盐。
• Aromatic polymer and process for its preparation
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0222536A2

  公开（公告）日：1987-05-20

  Aromatic polyethers are produced by polycondensing monomers containing phenolic groups and aromatic halogen, at least some of the aromatic halogen - containing monomers being free of activating groups such as -CO- or -SO2-, in the presence of a copper-containing catalyst and of a basic alkali metal compound present in stoichiometric excess relative to phenolic groups and copper. The products include new polyethers, particularly containing the repeating unit Ph1-PH1-O alone or with ketone containing or sulphone-containing units, where Ph' is phenylene.

  芳香族聚醚是在含铜催化剂和碱金属化合物（相对于酚类基团和铜）存在下，通过缩聚含有酚类基团和芳香卤素的单体（至少其中一些含芳香卤素的单体不含-CO-或-SO2-等活化基团）而制得的。产品包括新的聚醚，特别是单独含有重复单元 Ph1-PH1-O 或含有酮或含砜单元的聚醚，其中 Ph' 为亚苯基。
• Production and/or handling of polymers
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0292211A2

  公开（公告）日：1988-11-23

  In making polyarylethers or polyarylthioethers by reaction of thiophenols with aromatic halogen compounds, raw polycondensation product is freed of alkali halide by adjusting its composition and/or temperature so that it dissolves at least 0.5% w/w of water and holds the polymer in solution, and then contacting it in liquid form with hot water, preferably under pressure.

  在通过噻吩酚与芳香族卤素化合物的反应制备聚芳醚或聚芳硫醚时，先调节缩聚产物的成分和/或温度，使其溶解至少 0.5% w/w 的水，并将聚合物保持在溶液中，然后将其液态与热水接触，最好是在加压的情况下接触，这样就可以使缩聚产物不含卤化碱。
• Method for preparing sulfones
  申请人：Sanko Kaihatsu Kagaku Kenkyusho

  公开号：EP0508424A2

  公开（公告）日：1992-10-14

  A method for preparing sulfones represented by the following general formula: (wherein R' represents a lower alkyl group, an aryl group or an aryl group whose nucleus has substituents; and R'' may be identical to or different from R' and represents a lower alkyl group, an aryl group or an aryl group whose nucleus has substituents) comprises the step of condensing 4-hydroxybiphenyl or sulfonic acid esters of 4-hydroxybiphenyl represented by the following general formula: (wherein R is the same as R' or R'' defined above) with sulfonyl chlorides represented by the following general formula:         R'SO₂Cl (wherein R' is the same as that defined above) in the presence of a Lewis acid or a superstrong acid; and a method for preparing sulfones represented by the following general formula: (wherein R' is the same as that defined above) or alkali salts thereof comprises the step of saponifying the foregoing sulfones in the presence of an acid or alkali. These methods permits the production of sulfones or salts thereof in high yield and high quality through relatively simple operations. Thus, useful sulfones having biphenyl structures can be supplied at a low cost and in an industrial scale.

  一种制备由以下通式代表的砜的方法： (其中R'代表低级烷基、芳基或其核具有取代基的芳基；R''可以与R'相同或不同，并代表低级烷基、芳基或其核具有取代基的芳基）包括以下通式所代表的4-羟基联苯或4-羟基联苯的磺酸酯的缩合步骤： (其中 R 与上文所定义的 R' 或 R''相同）与下 列通式所代表的磺酰氯缩合： R'SO₂Cl (其中 R' 与上文所定义的相同)，在路易斯酸或超强酸存在下；以及制备由下式通式表示的砜的方法： (其中 R'与上述定义相同）或其碱盐的方法包括在酸或碱存在下对上述砜进行皂化的步骤。通过这些方法，可以通过相对简单的操作，生产出产量高、质量好的砜类或其盐类。因此，具有联苯结构的有用砜可以以低成本和工业规模供应。