| 1174047-26-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1174047-26-7
• 化学式: C₁₇H₁₄ClFN₂O₃
• 分子量: 348.761
• InChiKey: QEYWJGNRUGZXST-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 生成 (3-Amino-5-chloro-4-(methoxymethyl)-6-methylfuro[2,3-b]pyridin-2-yl)(4-fluorophenyl)methanone
  参考文献：
  名称：

  Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

  摘要：

  This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on manipulation of an MPEP/MTEP chemotype. This work demonstrates fundamentally new mGluR5 NAM chemotypes with submicromolar potencies, and the first example of a mode of pharmacology 'switch' to provide PAMs with a non-MPEP scaffold. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.110
• 作为产物：
  描述：

  5-chloro-4-(methoxymethyl)-6-methyl-2-oxo-1H-pyridine-3-carbonitrile 、 2-溴-4'-氟苯乙酮 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

  摘要：

  This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on manipulation of an MPEP/MTEP chemotype. This work demonstrates fundamentally new mGluR5 NAM chemotypes with submicromolar potencies, and the first example of a mode of pharmacology 'switch' to provide PAMs with a non-MPEP scaffold. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.110