四臂-聚乙二醇-巯基 | 188492-68-4

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 四臂-聚乙二醇-巯基
• 英文名称: 4-ArM PEGn-SH 2K, 5K, 10K, 20K
• 英文别名: 2-[2-[3-[2-(2-sulfanylethoxy)ethoxy]-2,2-bis[2-(2-sulfanylethoxy)ethoxymethyl]propoxy]ethoxy]ethanethiol
• CAS: 188492-68-4
• 化学式: C₂₁H₄₄O₈S₄
• 分子量: 552.8
• InChiKey: IUINCQVOTHNGMF-UHFFFAOYSA-N

物化性质

• 熔点：
  54 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  33
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77.8
• 氢给体数：
  4
• 氢受体数：
  12

安全信息

• 危险类别：
  9
• 危险性防范说明：
  P302+P352,P305+P351+P338,P273
• 危险品运输编号：
  3335
• 危险性描述：
  H410,H315,H319,H335,H372
• 包装等级：
  III

制备方法与用途

化学性质

四臂聚乙二醇巯基通常为白色或淡黄色固体或液粘稠体，具体取决于分子量大小。其结构中的巯基（SH）是一种高活性的官能团，可以与多种化学物质发生反应，如硫醇-硫醇偶联反应、硫醇-马来酰亚胺加成反应等。

结构特性

四臂聚乙二醇巯基由一个四臂聚乙二醇（PEG）的核心结构构成，每个臂的末端都连接有一个巯基（SH）官能团。

用途

四臂聚乙二醇巯基可以通过巯基与含有马来酰亚胺、碘乙酰胺等官能团的分子发生特异性偶联，用于生物分子的修饰和标记；在药物递送系统中，其可以作为连接剂，将药物分子与靶向分子或载体连接起来，实现药物的靶向递送。

文献信息

• Multifunctional Compounds for Forming Crosslinked Biomaterials and Methods of Preparation and Use
  申请人：Daniloff George Y.

  公开号：US20080312315A1

  公开（公告）日：2008-12-18

  Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
• MULTIFUNCTIONAL COMPOUNDS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE
  申请人：Daniloff George Y.

  公开号：US20130012683A1

  公开（公告）日：2013-01-10

  Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
• NUCLEOPHILE-TRIGGERED DEGRADABLE MATERIALS AND METHODS OF MAKING AND USING THE SAME
  申请人：GEORGIA TECH RESEARCH CORPORATION

  公开号：US20170360940A1

  公开（公告）日：2017-12-21

  Disclosed herein are degradable materials comprising the reaction product of an oxanorbornadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Also disclosed herein are degradable materials comprising a polymeric and hyperbranched crosslinked material made with oxanorbornadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Also disclosed herein are methods of making and using the same.
• HYDROGEL COMPOSITIONS AND DRUG DELIVERY SYSTEMS COMPRISING THE SAME
  申请人：Industrial Technology Research Institute

  公开号：US20180110731A1

  公开（公告）日：2018-04-26

  A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.
• US8303973B2
  申请人：——

  公开号：US8303973B2

  公开（公告）日：2012-11-06