4-(1H-benzimidazol-5-yloxy)-3-chlorobenzaldehyde | 934765-43-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(1H-benzimidazol-5-yloxy)-3-chlorobenzaldehyde
• 英文别名: 4-(3H-benzimidazol-5-yloxy)-3-chlorobenzaldehyde
• CAS: 934765-43-2
• 化学式: C₁₄H₉ClN₂O₂
• 分子量: 272.691
• InChiKey: ZAEMMLRJYZQDMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-{[2-chloro-4-(1,3-dioxolan-2-yl)phenyl]oxy}-1,2-benzenediamine 、 原甲酸三甲酯 在 1,3-二氧戊环 、 sodium hydroxide 、 乙酸乙酯 、 magnesium sulfate 作用下， 反应 2.0h， 以to give 4-(1H-benzimidazol-5-yloxy)-3-chlorobenzaldehyde的产率得到4-(1H-benzimidazol-5-yloxy)-3-chlorobenzaldehyde
  参考文献：
  名称：

  NOVEL HETEROCYCLE COMPOUNDS

  摘要：

  本发明涉及一种新型化合物，其在阿片受体上具有拮抗或反向激动剂作用。这些化合物在哺乳动物，特别是人类的肥胖症和相关疾病和/或病况的治疗中有用。还公开了制备和使用这些化合物的方法。

  公开号：

  US20090054431A1

文献信息

• NOVEL HETEROCYCLE COMPOUNDS
  申请人：Barvian Kevin Karl

  公开号：US20090054431A1

  公开（公告）日：2009-02-26

  The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or conditions in mammals, particularly humans. Methods of making and using such compounds are also disclosed.

  本发明涉及一种新型化合物，该化合物是阿片受体的拮抗剂或反向激动剂。这些化合物在治疗哺乳动物，特别是人类的肥胖和相关疾病和/或症状中是有用的。还公开了制备和使用这些化合物的方法。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• PHENOL ETHERS AS MODULATORS OF THE OPIOID RECEPTORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1943226A2

  公开（公告）日：2008-07-16
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.