| 1190937-29-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1190937-29-1
• 化学式: C₁₁H₁₆O₅
• 分子量: 228.245
• InChiKey: GOCZRZNOTQVVFT-XVBQNVSMSA-N

反应信息

• 作为产物：
  描述：

  (3aR,8aS)-2,2-dimethyl-3a,4,8,8a-tetrahydro-[1,3]dioxolo[4,5-c]oxepin-8-ol 、 乙酸酐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以44%的产率得到
  参考文献：
  名称：

  An oxepinone route to carbohydrate based oxepines

  摘要：

  Oxepines are ring expanded analogs of glycals that can be used to prepare septanose carbohydrates. A route to carbohydrate based oxepines that utilizes oxepinones as a key intermediate has been developed. The oxepinone intermediates were prepared via an amine catalyzed cycloisomerization of furanose hemi-ketals. 1,2-Reduction of the oxepinones followed by acetylation provided the novel ring expanded enol ether products. Moderate diastereoselectivity was observed for the reduction based on the starting oxepinone. 1,4-Addition onto the oxepinones was also demonstrated. Overall, the syntheses reported here will allow for ready access to novel ring expanded carbohydrate analogs. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.07.041