2-[cinnamoyl-L-Phe]thiazole | 1100728-13-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-[cinnamoyl-L-Phe]thiazole
• 英文别名: (E)-N-[(2S)-1-oxo-3-phenyl-1-(1,3-thiazol-2-yl)propan-2-yl]-3-phenylprop-2-enamide
• CAS: 1100728-13-9
• 化学式: C₂₁H₁₈N₂O₂S
• 分子量: 362.452
• InChiKey: GOEOCXVTUPJRPV-DXRVJIQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  87.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL COMPOUNDS
  申请人：Heiser Ulrich

  公开号：US20100273835A1

  公开（公告）日：2010-10-28

  The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the description and claims. The compounds of the present invention are useful as inhibitors of prolyl endopeptidase (PEP, EC 3.4.21.26) and/or IL-6.
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：PROBIODRUG AG

  公开号：WO2009007415A2

  公开（公告）日：2009-01-15

  The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the description and claims. The compounds of the present invention are useful as inhibitors of prolyl endopeptidase (PEP, EC 3.4.21.26) and/or IL-6.