8-methyl-5H-pyrido[3,2-b]indole | 1041015-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-methyl-5H-pyrido[3,2-b]indole
• CAS: 1041015-29-5
• 化学式: C₁₂H₁₀N₂
• 分子量: 182.225
• InChiKey: BEUSBAXTIHKRDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-(iodopentyl) cyclohexane 、 8-methyl-5H-pyrido[3,2-b]indole 在 sodium hydride 作用下， 以 乙二醇二甲醚 、 甲苯 为溶剂， 反应 36.0h， 生成 5-(5-cyclohexylpentyl)-1,8-dimethyl-5H-pyrido[3,2-b]indol-1-ium iodide
  参考文献：
  名称：

  δ-Carbolines and their ring-opened analogs: Synthesis and evaluation against fungal and bacterial opportunistic pathogens

  摘要：

  Previous studies have indicated that the delta-carboline (2) ring system derived from the natural product cryptolepine (1) may represent a pharmacophore for anti-infective activity. This paper describes the design and synthesis of a small library of substituted delta-carbolines and the evaluation of the anti-fungal and anti-bacterial activities. An evaluation of the anti-bacterial activity of a previously reported library of ring-opened analogs was also conducted to provide an opportunity to test the hypothesis that both group of compounds may have the same biological target. Results indicate that against a selected group of fungal pathogens, substituted delta-carbolinium analogs displayed higher potency and several fold lower cytotoxicity than cryptolepine the parent natural product. Both the delta-carbolinium compounds and their ring-opened analogs, exhibited equally high anti-bacterial activity against the selected pathogens and especially against the gram positive bacteria evaluated. Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2011.03.021
• 作为产物：
  描述：

  2-chloro-3-(4-methylphenylamino)pyridine 在 bis-triphenylphosphine-palladium(II) chloride sodium acetate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 0.17h， 以80%的产率得到8-methyl-5H-pyrido[3,2-b]indole
  参考文献：
  名称：

  钯催化高温下的分子内直接芳基化

  摘要：

  在高反应温度（180-200°C）下，已研究了钯催化的环加氢卤化反应，涉及芳族C-Br或活化的氮杂杂芳族C-Cl键的氧化加成和C（sp 2）-H活化。这使得各种azaheteroaromatic环系统（二苯并[的快速（10-30分钟）的合成˚F，ħ ]酞嗪，二苯并[ ˚F，ħ ]噌啉，苯并呋喃并[2,3- d ]哒嗪，5 ħ -pyridazino [ 4,5- b ]吲哚，7 ħ吲哚并[2,3- c ^ ]喹啉和5- ħ -δ咔啉）在中度至良好的产率。

  DOI：

  10.1016/j.tet.2008.01.060

文献信息

• MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE UTILIZING THE SAME
  申请人：Iwakuma Toshihiro

  公开号：US20090017330A1

  公开（公告）日：2009-01-15

  A material for organic electroluminescence devices of the invention which is for use in combination with at least one phosphorescent metal complex has a specific heterocyclic structure. The material for organic electroluminescence devices is used as a host material or a hole transporting material. An organic electroluminescence device having an anode, a cathode and an organic thin film layer having one or more layers which is interposed between the anode and cathode, in which at least one layer of the organic thin film layer contains the material for organic electroluminescence devices, has a high emitting efficiency, causes little pixel defects, is excellent in heat resistance, and shows a long lifetime.

  该发明的有机电致发光器件材料，用于与至少一种磷光金属配合使用，具有特定的杂环结构。该有机电致发光器件材料用作主体材料或空穴传输材料。具有阳极、阴极和有机薄膜层的有机电致发光器件，该有机薄膜层具有至少一层，位于阳极和阴极之间，其中有机薄膜层的至少一层含有该有机电致发光器件材料，具有高发光效率，几乎没有像素缺陷，具有优异的耐热性，并显示出长寿命。
• BISCARBAZOLE DERIVATIVE HOST MATERIALS AND RED EMITTER FOR OLED EMISSIVE REGION
  申请人：Yamamoto Hitoshi

  公开号：US20150194622A1

  公开（公告）日：2015-07-09

  The organic electroluminescence device utilizes a novel combination of a biscarbazole derivative compound as a phospherescent host materials and an orgaphosphorescent material as a red phosphorescent dopant material in the light emitting region of the device, where the biscarbazole derivative compound is represented by a formula (1); wherein the red phosphorescent dopant material is a phosphorescent organometallic complex having a substituted chemical structure represented by one of the partial chemical structures represented by a formulas (D1), (D2) and (D3).

  这个有机电致发光器件利用了一种新颖的组合，即在器件的发光区域中使用一种双咔唑衍生物化合物作为荧光主体材料，以及一种有机磷光材料作为红色磷光掺杂材料。其中，双咔唑衍生物化合物由公式（1）表示；红色磷光掺杂材料是一种磷光有机金属配合物，具有由公式（D1）、（D2）和（D3）中的任一部分化学结构进行替代的化学结构。
• MATERIALS FOR ELECTRONIC DEVICES
  申请人：MERCK PATENT GMBH

  公开号：US20160072076A1

  公开（公告）日：2016-03-10

  The present application relates to a compound of a formula (I) which comprises a benzene group that is substituted with a group selected from carbazole derivatives and bridged amines and with an electron attracting group, wherein the two groups are located in the ortho-position in relation to one another. The present application further relates to the use of the compound of the formula (I) in an electronic device, and to a method of producing the compound of the formula (I).

  本申请涉及一种化合物，其化学式为(I)，包括一个苯基，该苯基被取代为由咔唑衍生物和桥式胺组成的基团和一个吸电子基团，其中这两个基团位于相对的邻位。本申请还涉及在电子器件中使用化合物(I)的方法，以及制备化合物(I)的方法。
• Biscarbazole derivative, material for organic electroluminescence device and organic electroluminescence device using the same
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US10193077B2

  公开（公告）日：2019-01-29

  A biscarbazole derivative of the invention is represented by a formula (1) below. In the formula (1): A1 represents a substituted or unsubstituted nitrogen-containing heterocyclic group having 1 to 30 ring carbon atoms; A2 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 30 ring carbon atoms, or substituted or unsubstituted nitrogen-containing heterocyclic group having 1 to 30 ring carbon atoms; X1 and X2 each are a linking group; Y1 to Y4 each represent a substituent; p and q represent an integer of 1 to 4; and r and s represent an integer of 1 to 3.

  本发明的双咔唑衍生物由下式（1）表示。 在式(1)中A1 代表具有 1 至 30 个环碳原子的取代或未取代的含氮杂环基团；A2 代表具有 6 至 30 个环碳原子的取代或未取代的芳香烃基团，或具有 1 至 30 个环碳原子的取代或未取代的含氮杂环基团；X1 和 X2 分别为连接基团；Y1 至 Y4 分别代表取代基；p 和 q 代表 1 至 4 的整数；r 和 s 代表 1 至 3 的整数。
• Materials for electronic devices
  申请人：Merck Patent GmbH

  公开号：US10193079B2

  公开（公告）日：2019-01-29

  The present application relates to a compound of a formula (I) which comprises a benzene group that is substituted with a group selected from carbazole derivatives and bridged amines and with an electron attracting group, wherein the two groups are located in the ortho-position in relation to one another. The present application further relates to the use of the compound of the formula (I) in an electronic device, and to a method of producing the compound of the formula (I).

  本申请涉及一种式(I)化合物，它包括一个苯基，该苯基被一个选自咔唑衍生物和桥胺的基团以及一个引电子基团取代，其中这两个基团彼此位于正交位置。本申请还涉及式（I）化合物在电子设备中的用途，以及式（I）化合物的生产方法。