2-(2-methyl-2-formyl)ethyl-4-propoxymethylbutanolide | 945738-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-(2-methyl-2-formyl)ethyl-4-propoxymethylbutanolide
• CAS: 945738-28-3
• 化学式: C₁₂H₂₀O₄
• 分子量: 228.288
• InChiKey: RFYIYWQSWGVYFZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-(2-methyl-2-formyl)ethyl-4-propoxymethylbutanolide 在 甲酸 、 双氧水 作用下， 反应 12.0h， 以76%的产率得到2-methyl-3-(2-oxo-5-propoxymethyltetrahydro-3-furyl)propanoic acid
  参考文献：
  名称：

  Synthesis and some transformations of 2-alkenyl-4-alkoxymethylbutanolides

  摘要：

  The alkylation of 4-alkoxymethyl-2-ethoxycarbonylbutanolides led to the formation of 2-alkenyl-4-alkoxymethyl-2-ethoxycarbonylbutanolides which at alkaline hydrolysis provided new 2-alkenyl-4-alkoxymethylbutanolides. By oxidation of the latter with a mixture of hydrogen peroxide and formic acid 4-alkoxymethyl-2-(2-R-2,3-dihydroxy)propylbutanolides were obtained. The diololactones were shown to suffer under the conditions of the pinacol-pinacolone rearrangement a conversion into previously unknown formyl- and epoxylactones.

  DOI：

  10.1134/s1070428006080136
• 作为产物：
  描述：

  2-(2-methyl-2,3-dihydroxy)propyl-4-propoxymethylbutanolide 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 4.0h， 以73%的产率得到2-(2-methyl-2-formyl)ethyl-4-propoxymethylbutanolide
  参考文献：
  名称：

  Synthesis and some transformations of 2-alkenyl-4-alkoxymethylbutanolides

  摘要：

  The alkylation of 4-alkoxymethyl-2-ethoxycarbonylbutanolides led to the formation of 2-alkenyl-4-alkoxymethyl-2-ethoxycarbonylbutanolides which at alkaline hydrolysis provided new 2-alkenyl-4-alkoxymethylbutanolides. By oxidation of the latter with a mixture of hydrogen peroxide and formic acid 4-alkoxymethyl-2-(2-R-2,3-dihydroxy)propylbutanolides were obtained. The diololactones were shown to suffer under the conditions of the pinacol-pinacolone rearrangement a conversion into previously unknown formyl- and epoxylactones.

  DOI：

  10.1134/s1070428006080136