1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-butanone | 732180-91-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-butanone
• 英文别名: 1-(4-methylphenyl)-2-pyrrolidin-1-ylbutan-1-one
• CAS: 732180-91-5
• 化学式: C₁₅H₂₁NO
• 分子量: 231.33
• InChiKey: NXNPGAAZKYDOPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• IMMUNOASSAY FOR PYRROLIDINOPHENONES
  申请人：RANDOX LABORATORIES LIMITED

  公开号：US20160097783A1

  公开（公告）日：2016-04-07

  The current invention provides an improved immunoassay for the detection and determination of pyrrolidinophenone based designer drugs in hair and biological fluids (urine, blood, and oral fluid). The generic immunoassay is underpinned by novel, sub-family-specific antibodies, which display surprising sensitivity. The invention further describes substrates comprising an antibody that is specific to compounds of the pyrrolidinophenone family. Also described are the novel immunogens from which the antibodies are derived and kits incorporating the antibodies of the current invention.

  该发明提供了一种改进的免疫测定方法，用于检测和测定基于哌哆利啶酮类设计药物在头发和生物液体（尿液、血液和口腔液）中的含量。通用的免疫测定方法基于新颖的、亚家族特异性抗体，显示出惊人的灵敏度。该发明进一步描述了包含特异于哌哆利啶酮类化合物的抗体的底物。还描述了从中获得抗体的新颖免疫原以及包含本发明抗体的试剂盒。
• IMPROVED IMMUNOASSAY FOR PYRROLIDINOPHENONES
  申请人：Randox Laboratories Ltd.

  公开号：EP3002592A1

  公开（公告）日：2016-04-06

  The current invention provides an improved immunoassay for the detection and determination of pyrrolidinophenone based designer drugs in biological fluids (Urine, Blood, Oral fluid and Hair). The generic immunoassay is underpinned by novel, subfamily-specific antibodies which display surprising sensitivity. The invention further describes substrates comprising an antibody that is specific to compounds of the pyrrolidinophenone family. Also described are the novel immunogens from which the antibodies are derived and kits incorporating the antibodies of the current invention.

  本发明提供了一种改进的免疫测定法，用于检测和测定生物液体（尿液、血液、口服液和毛发）中的吡咯烷酮类特效药。这种通用免疫分析法以新型亚族特异性抗体为基础，显示出惊人的灵敏度。本发明进一步描述了包含对吡咯烷酮家族化合物具有特异性的抗体的底物。本发明还描述了衍生抗体的新型免疫原和包含本发明抗体的试剂盒。
• Material and method for colorimetric detection of small-molecule targets
  申请人：Xiao Yi

  公开号：US10725058B2

  公开（公告）日：2020-07-28

  The subject invention provides methods, assays, and products for visual detection of small-molecule targets in a sample in both clinical and field settings within minutes. The subject invention is based on an aptamer sensor that reports the presence of small-molecule target via a sensitive colorimetric signal for naked-eye detection. The aptamer sensor is a CBSAzyme-based sensor having both target-mediated cooperative behavior of the CBSA and peroxidase-mimicking catalytic activity of DNAzyme. The subject invention also provides methods of using the CBSAzyme-based sensor.

  本发明提供了在临床和现场环境中几分钟内目视检测样品中小分子靶标的方法、检测方法和产品。本发明基于一种适配体传感器，该传感器通过灵敏的比色信号报告小分子靶标的存在，用于肉眼检测。该适配体传感器是一种基于 CBSA 酶的传感器，同时具有 CBSA 的目标介导合作行为和 DNA 酶的过氧化物酶模拟催化活性。本发明还提供了使用基于 CBSA 酶的传感器的方法。
• Immunoassay for pyrrolidinophenones
  申请人：Randox Laboratories Ltd.

  公开号：EP2626358B1

  公开（公告）日：2015-09-02
• US9671415B2
  申请人：——

  公开号：US9671415B2

  公开（公告）日：2017-06-06