N-benzyl-2-cyano-3-(4-nitrophenyl)prop-2-enamide | 204010-55-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-benzyl-2-cyano-3-(4-nitrophenyl)prop-2-enamide
• CAS: 204010-55-9
• 化学式: C17H13N3O3
• mdl: MFCD01441331
• 分子量: 307.3
• InChiKey: GBMZRAHROINDEX-UHFFFAOYSA-N

物化性质

• 沸点：
  560.4±50.0 °C(Predicted)
• 密度：
  1.307±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.058
• 拓扑面积：
  98.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION
  申请人：Board of Regents, The University of Texas System

  公开号：EP2506852A2

  公开（公告）日：2012-10-10
• METHODS OF TREATING DERMATOLOGIC, GYNECOLOGIC, AND GENITAL DISORDERS WITH CAFFEIC ACID ANALOGS
  申请人：Priebe Anna

  公开号：US20110275577A1

  公开（公告）日：2011-11-10

  The present invention relates to caffeic acid analog compounds and methods which may be useful for regeneration, cellular programming, and the treatment of dermatologic, gynecologic, and genital diseases such as inflammatory dermatologic conditions, dysplasia, neoplasia, in situ carcinoma, invasive carcinoma, lichen sclerosus, lichen planus, vaginal dysplasia, vaginal carcinoma, vulvar dysplasia, vulvar carcinoma, cervical dysplasia, cervical carcinoma, and Kaposi's sarcoma.
• [EN] INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION<br/>[FR] TRAITEMENT À L'INTERFÉRON EN COMBINAISON AVEC UN BLOCAGE DE L'ACTIVATION DE STAT3
  申请人：UNIV TEXAS

  公开号：WO2011069141A2

  公开（公告）日：2011-06-09

  Methods of modulating the INF-induced STAT3 activation in a patient in need- thereof are provided for the treatment of disease. The methods comprise the step of administrating to a patient the combination of a therapeutically effective amount of interferon including INF-α and/or INF-β in combination with a STAT3 inhibitor.