(2-aminoethoxy)cyclobutane | 1354949-92-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-aminoethoxy)cyclobutane
• 英文别名: 2-cyclobutyloxyethanamine
• CAS: 1354949-92-0
• 化学式: C₆H₁₃NO
• mdl: MFCD16807242
• 分子量: 115.175
• InChiKey: XOUFUYNNQPAWFG-UHFFFAOYSA-N

物化性质

• 沸点：
  178.7±13.0 °C(Predicted)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoyl chloride 、 (2-aminoethoxy)cyclobutane 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以94%的产率得到N-[2-(cyclobutoxy)ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
  参考文献：
  名称：

  [EN] SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
  [FR] UTILISATION D'OXADIAZOLES SUBSTITUÉS POUR LUTTER CONTRE LES CHAMPIGNONS PHYTOPATHOGÈNES

  摘要：

  本发明涉及式I的新型噁二唑化合物或其N-氧化物和/或其农业上有用的盐，并且涉及它们用于控制植物病原真菌，或者用于对抗植物病原有害真菌的方法，该方法包括使用至少一种式I的化合物，或其N-氧化物，或其农业上可接受的盐的有效量，处理真菌或要保护免受真菌攻击的材料、植物、土壤或种子；本发明还涉及混合物，包括至少一种式I的化合物和至少一种从除草剂、安全剂、杀菌剂、杀虫剂和植物生长调节剂中选择的进一步杀虫活性物质；以及包括至少一种式I的化合物的农药组合物，以及进一步包括种子的农药组合物。

  公开号：

  WO2017076935A1

文献信息

• [EN] GLP-1R MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULATEURS DE GLP-1R
  申请人：GILEAD SCIENCES INC

  公开号：WO2021081207A1

  公开（公告）日：2021-04-29

  The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

  本公开提供GLP-1R激动剂，以及其组合物、方法和试剂盒。这些化合物通常用于治疗人体中GLP-1R介导的疾病或症状。
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
  申请人：Arvinas Operations, Inc.

  公开号：EP3660004A1

  公开（公告）日：2020-06-03

  The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

  本公开涉及双功能化合物，它们可用于降解和（抑制）雄激素受体。特别是，本公开涉及的化合物一端含有与 E3 泛素连接酶结合的脑龙配体，另一端含有与雄激素受体结合的分子，这样雄激素受体就被置于泛素连接酶附近，从而实现对雄激素受体的降解（和抑制）。本公开的化合物具有广泛的药理活性，与雄激素受体的降解/抑制作用相一致。
• TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
  申请人：Arvinas Operations, Inc.

  公开号：EP3689868A1

  公开（公告）日：2020-08-05

  The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, Inhibitors of Apoptosis Proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作雌激素受体（靶蛋白）的调节剂。特别是，本公开涉及双功能化合物，其一端含有 Von Hippel-Lindau 配体、cereblon 配体、凋亡蛋白抑制剂配体、小鼠双敏同源物 2 配体或其组合中的至少一种、其一端与相应的 E3 泛素连接酶结合，另一端与靶蛋白结合，从而将靶蛋白置于泛素连接酶附近，以实现对靶蛋白的降解（和抑制）。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防因目标蛋白聚集或积聚而导致的疾病或失调。
• SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
  申请人：BASF SE

  公开号：EP3371178A1

  公开（公告）日：2018-09-12
• Substituted Oxadiazoles for Combating Phytopathogenic Fungi
  申请人：BASF SE

  公开号：US20180317489A1

  公开（公告）日：2018-11-08

  The present invention relates to novel oxadiazoles of the formula I or an N-oxide and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, or to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula I, or an N-oxide, or an agriculturally acceptable salt thereof; the present invention also relates to mixtures comprising at least one such compound of the formula I and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of the formula I and to agrochemical compositions further comprising seeds.