| 882160-20-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 882160-20-5
• 化学式: C₄₈H₇₇NO₁₆
• 分子量: 924.136
• InChiKey: SWTGMGKUFVIXIE-HZUCBLTRSA-N

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal acetate buffer 、 氢气 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological investigation of new 4″-malonyl tethered derivatives of erythromycin and clarithromycin

  摘要：

  A new approach to 4 ''-substituted derivatives of erythromycin and clarithromycin was developed by converting them into corresponding 4"-malonic monoesters. Subsequent carbodiimide coupling with alcohols and amines provided new macrolide derivatives that are capable of binding to 50S ribosomal subunits and inhibiting protein synthesis in cell-free system. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.033
• 作为产物：
  描述：

  在 甲醇 作用下， 反应 24.0h， 生成
  参考文献：
  名称：

  Synthesis and biological investigation of new 4″-malonyl tethered derivatives of erythromycin and clarithromycin

  摘要：

  A new approach to 4 ''-substituted derivatives of erythromycin and clarithromycin was developed by converting them into corresponding 4"-malonic monoesters. Subsequent carbodiimide coupling with alcohols and amines provided new macrolide derivatives that are capable of binding to 50S ribosomal subunits and inhibiting protein synthesis in cell-free system. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.033