2-(2,2-dimethyl-1,3-dioxolan-4-yl)pyridine | 96517-57-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2,2-dimethyl-1,3-dioxolan-4-yl)pyridine
• CAS: 96517-57-6
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: QIEYMHZGMLJACH-UHFFFAOYSA-N

物化性质

• 沸点：
  267.8±30.0 °C(Predicted)
• 密度：
  1.075±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吡啶 、 2,2-二甲基-1,3-二氧环戊烷 、 硫酸 生成 2-(2,2-dimethyl-1,3-dioxolan-4-yl)pyridine
  参考文献：
  名称：

  ZORIN, V. V.;ZELECHONOK, YU. B.;ZLOTSKIJ, S. S.;RAXMANKULOV, D. L., ZH. ORGAN. XIMII, 1985, 21, N 1, 193-196

  摘要：

  DOI：

文献信息

• Method for producing 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, and said related substance
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：US10919872B2

  公开（公告）日：2021-02-16

  Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of a 2-alkylcarbonyl[2,3-b]furan-4,9-dione, which comprises reacting a 1-butyne derivative in which a ketone or an alcohol is protected with a 2-hydroxy-1,4-naphthoquinone derivative having a leaving group at position-3 in a solvent in the presence of a metal or a metal compound and a base; and a substance relating to the intermediate.

  本发明提供了一种生产 2-烷基羰基萘并[2,3-b]呋喃-4,9-二酮相关物质的方法，该方法适于工业化生产。本发明提供了：一种生产 2-烷基羰基[2,3-b]呋喃-4,9-二酮的中间体的方法，该方法包括在金属或金属化合物和碱存在下，在溶剂中使酮或醇被保护的 1-丁炔衍生物与位置-3 上有离去基团的 2-羟基-1,4-萘醌衍生物反应；以及一种与该中间体有关的物质。
• Zorin, V. V.; Zelechonok, Yu. B.; Zlot'skii, S. S., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, # 1, p. 174 - 176
  作者：Zorin, V. V.、Zelechonok, Yu. B.、Zlot'skii, S. S.、Rakhmankulov, D. L.

  DOI：——

  日期：——
• METHOD FOR PRODUCING 2-ALKYLCARBONYLNAPHTHO[2,3-b]FURAN-4,9-DIONE-RELATED SUBSTANCE, AND SAID RELATED SUBSTANCE
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：US20200239424A1

  公开（公告）日：2020-07-30

  Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of a 2-alkylcarbonyl[2,3-b]furan-4,9-dione, which comprises reacting a 1-butyne derivative in which a ketone or an alcohol is protected with a 2-hydroxy-1,4-naphthoquinone derivative having a leaving group at position-3 in a solvent in the presence of a metal or a metal compound and a base; and a substance relating to the intermediate.