3,5-dihydroxy-4-heptanone | 649767-29-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,5-dihydroxy-4-heptanone
• 英文别名: 3,5-Dihydroxyheptan-4-one
• CAS: 649767-29-3
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: RNFRDLHBYINGNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,5-Diiodo-heptan-4-one 在 air 、 三乙胺 作用下， 以 丙酮 为溶剂， 反应 6.0h， 以58%的产率得到3,5-dihydroxy-4-heptanone
  参考文献：
  名称：

  Photo-irradiation of α-halo carbonyl compounds: a novel synthesis of α-hydroxy- and α,α′-dihydroxyketones

  摘要：

  The reaction of g.-halo ketones (alpha-iodocycloalkanones, alpha-bromocycloalkanones, alpha-iodo-beta-alkoxy esters, and alpha-iodoacyclic-ketones) with irradiation under a high-pressure mercury lamp gave the corresponding alpha-hydroxyketones in good yields. For alpha-bromoketones, it was found that alpha-hydroxylation does not occur. However, alpha-bromoketones were convened into a-hydroxyketones in the presence of KI. In the case of alpha,alpha(1)-diiodo ketones, alpha,alpha(1)-dihydroxyketones, which up to now have scarcely been reported, were obtained. This reaction affords a new, clean and convenient synthetic method for alpha-hydroxy- and alpha,alpha(1)-dihydroxyketones. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.01.010

文献信息

• Verfahren zur Herstellung von Oxoisophoron
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1063218A1

  公开（公告）日：2000-12-27

  Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 3,5,5-Trimethylcyclohex-2-en-1,4-dion (Oxoisophoron; OIP) durch Oxidation von 3,5,5-Trimethyl-cyclohex-3-en-1-on (β-Isophoron, β-IP) mit molekularem Sauerstoff in Gegenwart eines Lösungsmittels, einer Base und einem Mangan-Salenderivat als Katalysator.

  本发明涉及一种制备 3,5,5-三甲基环己-2-烯-1,4-二酮（氧化异佛尔酮；OIP）的工艺，该工艺是在溶剂、碱和作为催化剂的锰压延衍生物存在下，用分子氧氧化 3,5,5-三甲基环己-3-烯-1-酮（β-异佛尔酮，β-IP）。
• A novel synthesis of α-hydroxy- and α,α′-dihydroxyketone from α-iodo and α,α′-diiodo ketone using photoirradiation
  作者：C.Akira Horiuchi、Akinori Takeda、Wen Chai、Kishoh Ohwada、Shun-Jun Ji、T.Tomoyoshi Takahashi

  DOI：10.1016/j.tetlet.2003.10.082

  日期：2003.12

  A novel reaction of alpha-iodo ketone (alpha-iodocycloalkanone, alpha-iodo-beta-alkoxy ester, and alpha-iodoacyclicketone) with irradiation under a high-pressure mercury lamp gave the corresponding alpha-hydroxyketone in good yields. In the case of alpha,alpha'-diiodo ketone, alpha,alpha'-dihydroxyketone which little has been reported until now was obtained. This reaction affords a new, clean and convenient synthetic method for alpha-hydroxy- and alpha,alpha'-dihydroxyketone. (C) 2003 Elsevier Ltd. All rights reserved.
• Heterocyclisch substituierte Hydroxyalkyl-azolyl-Derivate
  申请人：BAYER AG

  公开号：EP0111711B1

  公开（公告）日：1987-03-18
• DISPENSER FOR INSECT SEMIOCHEMICALS, METHOD FOR THE PREPARATION THEREOF AND METHOD FOR THE CONTROL OF INSECTS
  申请人：NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

  公开号：EP0484361A1

  公开（公告）日：1992-05-13
• INKJET INK, INK CARTRIDGE, INKJET RECORDING APPARATUS, INKJET RECORDING METHOD AND IMAGE FORMING APPARATUS
  申请人：Ricoh Company, Ltd.

  公开号：EP2328982A1

  公开（公告）日：2011-06-08