N-[2-cyano-1-(1H-indol-3-ylmethyl)-ethyl]-5-quinolin-6-yl-2-trifluoromethoxybenzamide | 1108612-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[2-cyano-1-(1H-indol-3-ylmethyl)-ethyl]-5-quinolin-6-yl-2-trifluoromethoxybenzamide
• 英文别名: N-[1-cyano-3-(1H-indol-3-yl)propan-2-yl]-5-quinolin-6-yl-2-(trifluoromethoxy)benzamide
• CAS: 1108612-88-9
• 化学式: C₂₉H₂₁F₃N₄O₂
• 分子量: 514.507
• InChiKey: BTKMXFPEEDCOOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  90.8
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Cyanomethyl substituted N-Acyl Tryptamines
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2020404A1

  公开（公告）日：2009-02-04

  The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula I in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及具有以下结构的氰甲基取代的N-酰基色胺化合物，其中R1、R2、R3、R4、R5、Q、X和W的含义如描述中所定义。根据本发明的化合物是有效的FSH拮抗剂，可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• CYANOMETHYL SUBSTITUTED N-ACYL TRYPTAMINES
  申请人：WORTMANN Lars

  公开号：US20090069321A1

  公开（公告）日：2009-03-12

  The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula I in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及公式I中的氰甲基取代N-酰基色胺类化合物，其中R1、R2、R3、R4、R5、Q、X和W的含义如描述中所定义。本发明的化合物是有效的FSH拮抗剂，例如可以用于男性或女性的生育控制，或用于骨质疏松的预防和/或治疗。
• (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2051962A1

  公开（公告）日：2009-04-29
• [EN] (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES<br/>[FR] DÉRIVÉS DE L'ACIDE (3-AMINO-1,2,3,4-TÉTRAHYDRO-9H-CARBAZOL-9-YL)-ACÉTIQUE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2008017989A1

  公开（公告）日：2008-02-14

  [EN] The present invention relates to (3-amino-l,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R¹, R², R³, R⁴, R⁵ and R⁶ are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D₂ receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
  [FR] La présente invention concerne des dérivés de l'acide (3-amino-1,2,3,4-tétrahydro-9H-carbazol-9-yl)-acétique de la Formule I (I) dans laquelle R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, et leur utilisation en tant que modulateurs des récepteurs de la prostaglandine, plus particulièrement comme modulateurs des récepteurs de la prostaglandine D2, dans le traitement de diverses maladies et troubles à médiation par la prostaglandine. La présente invention concerne également des compositions pharmaceutiques contenant ces composés et des procédés permettant de les préparer.
• [EN] CYANOMETHYL SUBSTITUTED N-ACYL TRYPTAMINES<br/>[FR] N-ACYLTRYPTAMINES À SUBSTITUTION CYANOMÉTHYLE
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2009016253A2

  公开（公告）日：2009-02-05

  The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula (I) in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.