WP 1073 | 857064-77-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: WP 1073
• 英文别名: (E)-N-benzyl-2-cyano-3-(5-hydroxy-2-nitrophenyl)prop-2-enamide
• CAS: 857064-77-8
• 化学式: C₁₇H₁₃N₃O₄
• 分子量: 323.308
• InChiKey: DEHXUXOXQCKHAX-RIYZIHGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compounds for treatment of cell proliferative diseases
  申请人：BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

  公开号：EP2487156A1

  公开（公告）日：2012-08-15

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.

  本发明涉及化合物及其用于治疗癌症等细胞增殖性疾病。本发明的化合物作为激酶抑制剂具有显著的效力，可导致 c-myc 下调，抑制癌细胞株的生长和存活。
• COMPOUNDS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES
  申请人：Priebe Waldemar

  公开号：US20110021805A1

  公开（公告）日：2011-01-27

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
• METHODS OF TREATING DERMATOLOGIC, GYNECOLOGIC, AND GENITAL DISORDERS WITH CAFFEIC ACID ANALOGS
  申请人：Priebe Anna

  公开号：US20110275577A1

  公开（公告）日：2011-11-10

  The present invention relates to caffeic acid analog compounds and methods which may be useful for regeneration, cellular programming, and the treatment of dermatologic, gynecologic, and genital diseases such as inflammatory dermatologic conditions, dysplasia, neoplasia, in situ carcinoma, invasive carcinoma, lichen sclerosus, lichen planus, vaginal dysplasia, vaginal carcinoma, vulvar dysplasia, vulvar carcinoma, cervical dysplasia, cervical carcinoma, and Kaposi's sarcoma.
• INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION
  申请人：Priebe Waldemar

  公开号：US20130129675A1

  公开（公告）日：2013-05-23

  Methods of modulating the INF-induced STAT3 activation in a patient in need-thereof are provided for the treatment of disease. The methods comprise the step of administrating to a patient the combination of a therapeutically effective amount of interferon including INF-α and/or INF-β in combination with a STAT3 inhibitor.
• US7745468B2
  申请人：——

  公开号：US7745468B2

  公开（公告）日：2010-06-29