1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)- carbamoyl)piperidine-4-sulfonamide | 2260969-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)- carbamoyl)piperidine-4-sulfonamide
• 英文别名: selnoflast；RO7486967；1-(1-ethylpiperidin-4-yl)sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea
• CAS: 2260969-36-4
• 化学式: C₂₀H₂₉N₃O₃S
• 分子量: 391.535
• InChiKey: OHIFQOUPTWBQLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  86.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  benzyl 4-sulfamoylpiperidine-1-carboxylate 在 20% palladium hydroxide-activated charcoal 、 potassium tert-butylate 、 氢气 作用下， 以 四氢呋喃 、 水 为溶剂， 15.0~25.0 ℃ 、100.0 kPa 条件下， 生成 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)- carbamoyl)piperidine-4-sulfonamide
  参考文献：
  名称：

  [EN] PROCESSES FOR THE PREPARATION OF 1,2,3,5,6,7-HEXAHYDRO-S-INDACENE DERIVATIVES
  [FR] PROCÉDÉS POUR LA PRÉPARATION DE DÉRIVÉS DE 1,2,3,5,6,7-HEXAHYDRO-S-INDACÈNE

  摘要：

  The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3inhibition.

  公开号：

  WO2023156311A1

文献信息

• [EN] NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE SULFONAMIDE CARBOXAMIDE
  申请人：INFLAZOME LTD

  公开号：WO2019008025A1

  公开（公告）日：2019-01-10

  The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

  本发明涉及式（I）的化合物，其中Q从O或S中选择；R1是一个非芳香杂环基团，包括至少一个环氮原子，其中R1通过一个环碳原子连接到磺酰脲基团的硫原子，并且R1可以选择性地被取代；R2是在α位被取代的环基团，其中R2也可以选择性地被进一步取代。本发明还涉及这些化合物的盐、溶剂合物和前药，包括这些化合物的药物组合物，以及利用这些化合物治疗和预防医学疾病和疾病的用途，尤其是通过抑制NLRP3。
• NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS
  申请人：Inflazome Limited

  公开号：EP3661925B1

  公开（公告）日：2021-11-24
• WO2022268935A2
  申请人：——

  公开号：WO2022268935A2

  公开（公告）日：2022-12-29
• WO2022269010A1
  申请人：——

  公开号：WO2022269010A1

  公开（公告）日：2022-12-29