1-(4'-fluorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide | 1253784-34-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4'-fluorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide
• 英文别名: 1-(4-fluorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide
• CAS: 1253784-34-7
• 化学式: Br*C₁₆H₁₆FN₂O₄
• 分子量: 399.216
• InChiKey: YERXXPJBHAPXEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.69
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  94.0
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-溴-4'-氟苯乙酮 、 Pyridoxaloxime 以 丙酮 为溶剂， 反应 0.05h， 以70%的产率得到1-(4'-fluorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide
  参考文献：
  名称：

  在微波辐射下有效合成吡哆醛肟衍生物。

  摘要：

  吡哆醛肟的季盐已通过使用微波加热将吡哆醛肟与取代的苯甲酰溴季铵化而合成。微波辅助快速合成在溶剂（丙酮）和无溶剂条件下进行。在丙酮中在非常短的反应时间（3-5 分钟）以及在无溶剂程序中（42%-78%）在非常短的反应时间（7- 10 分钟）。介绍了制备吡哆醛肟季盐的有效方法，具有环保、易于处理和反应时间较短的优点。通过单晶 X 射线衍射法明确证实了化合物 7 的结构，其中 4-氟苯酰基部分与吡啶环氮原子键合。

  DOI：

  10.3390/molecules19067610

文献信息

• Menshutkin Reaction in Choline Chloride-based Deep Eutectic Solvents
  作者：V. Bušić、D. Gašo-Sokač

  DOI：10.1080/00304948.2022.2117968

  日期：2023.3.4

  Published in Organic Preparations and Procedures International: The New Journal for Organic Synthesis (Vol. 55, No. 2, 2023)

  发表于国际有机制剂和程序：有机合成新期刊（印刷前，2022 年）
• Novel and Cleaner Synthesis of Pyridinium Salts from Pyridoxal Oxime and Substituted Phenacyl Bromides
  作者：Valentina Bušić、Dajana Gašo-Sokač、Spomenka Kovač

  DOI：10.5562/cca2364

  日期：——

  An efficient green synthesis of quaternary pyridinium salts by liquid-assisted grinding (LAG) is reported. A series of reactions of pyridoxal oxime with substituted phenacyl bromides was carried out in a mortar and pestle. This new and cleaner method provides several advantages such as being environmentally friendly, using a simple workup procedure, and affording moderate to excellent yields. All products were deduced from their IR, NMR spectroscopic and elemental analysis data.
• Synthesis and evaluation of novel analogues of vitamin B6 as reactivators of tabun and paraoxon inhibited acetylcholinesterase
  作者：Dajana Gašo-Sokač、Maja Katalinić、Zrinka Kovarik、Valentina Bušić、Spomenka Kovač

  DOI：10.1016/j.cbi.2010.02.004

  日期：2010.9

  A series of novel pyridinium oximes was prepared by reactions of quaternization of pyridoxal oxime with substituted phenacyl bromides in acetone at room temperature. The structures of compounds were determined according to the data obtained by IR spectroscopy, mass spectrometry, H-1 and C-13 nuclear magnetic resonance spectroscopy as well as by elemental analysis. We tested pyridoxal oxime (1) and five prepared oximes in 1 mM concentration as reactivators of human erythrocytes acetylcholinesterase (AChE) inhibited by organophosphorus compounds tabun and paraoxon: 1-phenacyl-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide (2), 1-(4'-chlorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide (3), 1-(4'-fluorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide (4), 3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methyl-1-(4'-methylphenacyl)pyridinium bromide (5), 3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methyl-1-(4'-methoxyphenacyl)pyridinium bromide (6). However, tested oximes were not efficient in reactivation of either tabun or paraoxon inhibited AChE. The maximum restored enzyme activity in 24 h was below 25%. Therefore, this class of compounds cannot be considered as potential improvement in a search for new and more efficient antidotes against OP poisoning. (C) 2010 Elsevier Ireland Ltd. All rights reserved.