10-{1-Amino-4-azatricyclo[6.1.0.02,6]nonan-4-yl}-9-fluoro-2,3-dihydro-3-(S)-methyl-7-oxo-7H-pyrido[1.2.3-de][1,4]benzoxazine-6-carboxylic Acid | 207609-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-{1-Amino-4-azatricyclo[6.1.0.02,6]nonan-4-yl}-9-fluoro-2,3-dihydro-3-(S)-methyl-7-oxo-7H-pyrido[1.2.3-de][1,4]benzoxazine-6-carboxylic Acid
• 英文别名: (2S)-6-(2-amino-8-azatricyclo[4.3.0.02,4]nonan-8-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
• CAS: 207609-30-1
• 化学式: C₂₁H₂₂FN₃O₄
• 分子量: 399.422
• InChiKey: BFWCAUWYKZQUPQ-AODIIDICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  96.1
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Tricyclic amine derivatives
  申请人：——

  公开号：US20010037030A1

  公开（公告）日：2001-11-01

  The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. 1 wherein Q preferably represents the following partial structure which may have various substituents: 2

  本发明涉及一种具有三环胺取代基的化合物，该化合物可以具有各种取代基，表示为式(I)的盐或水合物，盐的水合物和包含它们作为活性成分的药物。它们对革兰氏阴性菌和革兰氏阳性菌表现出优异的抗菌活性，具有令人满意的效果和安全性，适用于治疗传染病。其中Q最好表示以下可能具有各种取代基的部分结构：2
• TRICYCLIC AMINE DERIVATIVES
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0947513A1

  公开（公告）日：1999-10-06

  The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. wherein Q preferably represents the following partial structure which may have various substituents:

  本发明涉及一种具有可具有各种取代基的三环胺取代基的化合物，该化合物由式（I）、其盐或水合物、盐的水合物以及含有它们作为活性成分的药物表示。它们对革兰氏阴性菌和革兰氏阳性菌都有很好的抗菌活性，而且安全性令人满意，可用于治疗传染性疾病。 其中 Q 优选代表以下部分结构，可具有各种取代基：
• US6384050B1
  申请人：——

  公开号：US6384050B1

  公开（公告）日：2002-05-07
• US6586604B2
  申请人：——

  公开号：US6586604B2

  公开（公告）日：2003-07-01