4-(4,5-dimethyl-1H-imidazol-1-yl)aniline | 1429649-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4,5-dimethyl-1H-imidazol-1-yl)aniline
• 英文别名: 4-(4,5-dimethylimidazol-1-yl)aniline
• CAS: 1429649-60-4
• 化学式: C₁₁H₁₃N₃
• mdl: MFCD16715627
• 分子量: 187.244
• InChiKey: FHTLMLJMAPKUTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 铁粉 、 溶剂黄146 作用下， 反应 2.0h， 以40%的产率得到4-(4,5-dimethyl-1H-imidazol-1-yl)aniline
  参考文献：
  名称：

  Synthesis of 2-unsubstituted 1-arylimidazoles

  摘要：

  A method has been developed for the synthesis of 1-arylimidazoles lacking a substituent at position 2, featuring the preparation of 1-arylimidazole N-oxides stabilized as boron trifluoride derivatives, with subsequent reduction to the desired imidazoles. This method permits broad variation of the substituents in the aryl part of these molecules.

  DOI：

  10.1007/s10593-013-1210-8

文献信息

• Small molecule modulators of IL-17
  申请人：LEO Pharma A/S

  公开号：US11377425B1

  公开（公告）日：2022-07-05

  The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

  本发明涉及一种符合式 I 的化合物 及其药学上可接受的盐、水合物或溶液。本发明还涉及用于治疗的所述化合物、包含所述化合物的药物组合物、用所述化合物治疗疾病（如皮肤病）的方法，以及在制造药物时使用所述化合物。
• [EN] AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17<br/>[FR] ANILIDES D'ACIDES AMINÉS EN TANT QUE MODULATEURS À PETITES MOLÉCULES D'IL-17
  申请人：LEO PHARMA AS

  公开号：WO2020127685A1

  公开（公告）日：2020-06-25

  The present invention relates to a compound according to formula I (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.