(S)-1-{4-[(R)-2-Hydroxy-2-(6-methoxy-quinolin-4-yl)ethyl]-piperazin-1-yl}-3-phenylamino-propan-2-ol | 438580-35-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-1-{4-[(R)-2-Hydroxy-2-(6-methoxy-quinolin-4-yl)ethyl]-piperazin-1-yl}-3-phenylamino-propan-2-ol
• 英文别名: (2S)-1-anilino-3-[4-[(2R)-2-hydroxy-2-(6-methoxyquinolin-4-yl)ethyl]piperazin-1-yl]propan-2-ol
• CAS: 438580-35-9
• 化学式: C₂₅H₃₂N₄O₃
• 分子量: 436.554
• InChiKey: QYBYLPXOMFSCID-CPJSRVTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  81.1
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Quinolines and nitrogenated derivatives thereof substituted in 4-position by a piperazine-containing moiety and their use as antibacterial agents
  申请人：——

  公开号：US20040077656A1

  公开（公告）日：2004-04-22

  Piperazine derivatives, containing a quinoline analog moiety, of formula (I) and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammal, particularly in man.

  含有喹啉类似物基团的哌嗪衍生物，化学式为（I），以及药用上可接受的衍生物，适用于治疗哺乳动物中的细菌感染，特别是人类。
• QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERAZINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1343765A1

  公开（公告）日：2003-09-17
• [EN] QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERAZINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS<br/>[FR] QUINOLEINES ET DERIVES AZOTES DE CELLES-CI SUBSTITUES A LA POSITION 4 PAR UN FRAGMENT CONTENANT DE LA PIPERAZINE ET UTILISATION DE CEUX-CI EN TANT QU'AGENTS ANTIBACTERIENS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2002050040A1

  公开（公告）日：2002-06-27

  Piperazine derivatives, containing a quinoline analog moiety, of formula (I) and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammal, particularly in man.