6-fluoro-2-(4-methoxy-phenyl)-quinoline-4-carboxylic acid (6-fluoro-pyridin-2-yl)-amide | 1208372-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-fluoro-2-(4-methoxy-phenyl)-quinoline-4-carboxylic acid (6-fluoro-pyridin-2-yl)-amide
• 英文别名: 6-fluoro-N-(6-fluoropyridin-2-yl)-2-(4-methoxyphenyl)quinoline-4-carboxamide
• CAS: 1208372-75-1
• 化学式: C₂₂H₁₅F₂N₃O₂
• 分子量: 391.377
• InChiKey: HQMSLUUYQLOCSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL PHENYL-QUINOLINE-CARBOXYLIC ACID PYRIDINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Nardi Antonio

  公开号：US20110207773A1

  公开（公告）日：2011-08-25

  This invention relates to novel phenyl-quinoline-carboxylic acid pyridine derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  这项发明涉及新型苯基-喹啉-羧酸吡啶衍生物，发现它们是尼古丁型乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病或紊乱、神经退行性疾病、炎症、疼痛以及化学物质滥用终止引起的戒断症状等多种疾病或紊乱具有用处。