3-(Pyridin-3-yloxy)propanoic acid | 933711-54-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(Pyridin-3-yloxy)propanoic acid
• 英文别名: 3-pyridin-3-yloxypropanoic acid
• CAS: 933711-54-7
• 化学式: C₈H₉NO₃
• mdl: MFCD09034760
• 分子量: 167.16
• InChiKey: BOJXNJWVAMSISR-UHFFFAOYSA-N

物化性质

• 沸点：
  300.7±17.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-amino-1H-pyrazol-1-yl)-N-methyl-N-(2-(p-tolyloxy)ethyl)acetamide 、 3-(Pyridin-3-yloxy)propanoic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以8 %的产率得到N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-(pyridin-3-yloxy)propanamide
  参考文献：
  名称：

  LINEAR HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS

  摘要：

  Provided herein are compounds that activate IRE1/XBP1 s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.

  公开号：

  WO2024118801A1
• 作为产物：
  描述：

  3-(but-3-en-1-yloxy)pyridine 在 ruthenium trichloride 、 sodium periodate 、 水 作用下， 以 四氯化碳 、 乙腈 为溶剂， 以9 %的产率得到3-(Pyridin-3-yloxy)propanoic acid
  参考文献：
  名称：

  LINEAR HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS

  摘要：

  Provided herein are compounds that activate IRE1/XBP1 s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.

  公开号：

  WO2024118801A1

文献信息

• PROCESS FOR PREPARING ACRYLIC ACID FROM ETHYLENE OXIDE AND CARBON MONOXIDE
  申请人：BASF SE

  公开号：US20140018570A1

  公开（公告）日：2014-01-16

  A process for preparing acrylic acid from ethylene oxide and carbon monoxide, in which ethylene oxide is carbonylated in an aprotic solvent with carbon monoxide in the presence of a cobalt catalyst system to give poly-3-hydroxypropionate, the cobalt content in the poly-3-hydroxypropionate formed is reduced with the aid of water and/or an aqueous solution as a precipitation and/or wash liquid, and the poly-3-hydroxypropionate is subsequently split by thermolysis to give acrylic acid.
• US9115070B2
  申请人：——

  公开号：US9115070B2

  公开（公告）日：2015-08-25